| The metabolic syndrome is associated with advanced vascular damage in patients with coronary heart disease, stroke, peripheral arterial disease or abdominal aortic aneurysm. | |
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MedLine Citation:
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PMID: 14984924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The metabolic syndrome is associated with an increased risk of cardiovascular disease in patients without a cardiovascular history. We investigated whether the metabolic syndrome is related to the extent of vascular damage in patients with various manifestations of vascular disease. METHODS AND RESULTS: The study population of this cross-sectional survey consisted of 502 patients recently diagnosed with coronary heart disease (CHD), 236 with stroke, 218 with peripheral arterial disease (PAD) and 89 with abdominal aortic aneurysm (AAA). Metabolic syndrome was diagnosed according to Adult Treatment Panel III criteria. Carotid Intima Media Thickness (IMT), Ankle Brachial Pressure Index (ABPI) and albuminuria were used as non-invasive markers of vascular damage and adjusted for age and sex if appropriate. The prevalence of the metabolic syndrome in the study population was 45%. In PAD patients this was 57%; in CHD patients 40%, in stroke patients 43% and in AAA patients 45%. Patients with the metabolic syndrome had an increased mean IMT (0.98 vs 0.92mm, P-value <0.01), more often a decreased ABPI (14% vs 10%, P-value 0.06) and increased prevalence of albuminuria (20% vs 15%, P-value 0.03) compared to patients without this syndrome. An increase in the number of components of the metabolic syndrome was associated with an increase in mean IMT (P-value for trend <0.001), lower ABPI (P-value for trend <0.01) and higher prevalence albuminuria (P-value for trend <0.01). CONCLUSION: In patients with manifest vascular disease the presence of the metabolic syndrome is associated with advanced vascular damage. |
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Authors:
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Jobien K Olijhoek; Yolanda van der Graaf; Jan-Dirk Banga; Ale Algra; Ton J Rabelink; Frank L J Visseren; |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European heart journal Volume: 25 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-02-26 Completed Date: 2004-06-01 Revised Date: 2009-06-26 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 342-8 Citation Subset: IM |
Affiliation:
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Internal Medicine, Section of Vascular Medicine, UMC Utrecht, Utrecht, The Netherlands. J.K.Olijhoek@azu.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aortic Aneurysm, Abdominal
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etiology*,
pathology Coronary Disease / etiology*, pathology Cross-Sectional Studies Female Humans Male Metabolic Syndrome X / complications*, pathology Middle Aged Peripheral Vascular Diseases / etiology*, pathology Prognosis Stroke / etiology*, pathology Tunica Intima / pathology |
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