| The metabolic syndrome is amplified in hypothyroid rheumatoid arthritis patients: a cross-sectional study. | |
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MedLine Citation:
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PMID: 19103637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Rheumatoid arthritis (RA) patients are at increased risk of cardiovascular disease (CVD), which is even more pronounced in hypothyroid RA patients. An unfavourable cardiovascular risk profile conferred by a higher prevalence of the metabolic syndrome (MetS) and a higher Framingham risk score might explain this amplified cardiovascular morbidity. This study compared first, MetS (features) and second, the Framingham 10-year CVD risk in RA patients with hypothyroidism compared with euthyroid RA patients. METHODS: RA patients participating in the CARRE investigation were divided into two groups: hypothyroid and euthyroid RA patients. MetS according to the National Cholesterol Education Program Third Adult Treatment Panel criteria and the Framingham risk score was compared between hypothyroid and non-hypothyroid CVD event-free RA patients. RESULTS: In total, 257 RA patients were included: 236 with RA (91.8%) and 21 with hypothyroid RA (8.2%), respectively. The prevalence of the MetS was significantly higher in hypothyroid RA patients (43%) compared with RA patients (20%). Moreover, female hypothyroid RA patients had a higher Framingham risk score compared with euthyroid RA patients. With RA patients as the reference category, the age and gender-adjusted prevalence odds ratio for the MetS was 3.5 (95% CI 1.3 to 9.1) in hypothyroid RA. CONCLUSIONS: Hypothyroid RA patients, particularly female patients, have a more unfavourable cardiovascular risk profile, reflected by an increased prevalence of the MetS and higher Framingham score, than euthyroid RA patients, suggesting a greater need for cardiovascular risk management in these patients to prevent future CVD events. |
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Authors:
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H G Raterman; I C van Eijk; A E Voskuyl; M J L Peters; B A C Dijkmans; V P van Halm; S Simsek; W F Lems; M T Nurmohamed |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 69 ISSN: 1468-2060 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 39-42 Citation Subset: IM |
Affiliation:
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VU University Medical Centre, Departments of Internal Medicine and Rheumatology, 1007 MB Amsterdam, The Netherlands. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arthritis, Rheumatoid / complications* Cardiovascular Diseases / etiology Epidemiologic Methods Female Humans Hypothyroidism / complications Male Metabolic Syndrome X / etiology* Middle Aged Sex Factors |
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