Document Detail


The metabolic life and times of a T-cell.
MedLine Citation:
PMID:  20636818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The regulation of lymphocyte homeostasis is critical for the development and formation of productive immune responses. Cell numbers must be maintained to allow sufficient numbers of lymphocytes to combat foreign pathogens but prevent the accumulation of excess lymphocytes that may increase the risk of developing autoimmunity or neoplasia. Cell extrinsic growth factors are essential to maintain homeostasis and cell survival, and it has become increasingly apparent that a key mechanism of this control is through regulation of cell metabolism. The metabolic state of T cells can have profound influences on cell growth and survival and even differentiation. In particular, resting T cells utilize an energy efficient oxidative metabolism but shift to a highly glycolytic metabolism when stimulated to grow and proliferate by pathogen encounter. After antigen clearance, T cells must return to a more quiescent oxidative metabolism to support T-cell memory. This review highlights how these metabolic changes may be intricately involved with both T-cell growth and death in the control of homeostasis and immunity.
Authors:
Ryan D Michalek; Jeffrey C Rathmell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  236     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-29     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  190-202     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / immunology
Cell Survival / immunology
Homeostasis / immunology*
Humans
Immunity / immunology*
Lymphocyte Count
Models, Immunological
T-Lymphocytes / cytology,  immunology*,  metabolism*
Time Factors
Grant Support
ID/Acronym/Agency:
R01 AI063345/AI/NIAID NIH HHS; R01 CA123350-04/CA/NCI NIH HHS; R01 CA123350-05/CA/NCI NIH HHS
Comments/Corrections

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