| The metabolic effects of estriol in female rat liver. | |
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MedLine Citation:
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PMID: 10402170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of estriol on oxygen uptake, glucose release, lactate and pyruvate production, beta-hydroxybutyrate and acetoacetate production in perfused rat liver as well as, carbon uptake in rat liver and intracellular calcium in isolated Kupffer cells were investigated. Basal oxygen consumption of perfused liver increased significantly in estriol or ethanol-treated rats. But these increased effects were blocked by gadolinium chloride pretreatment. In a metabolic study, pretreatment with estriol resulted in a decrease in glucose production and in glycolysis while an increase in ketogenesis. A more oxidized redox state of the mitochondria was indicated by increased ratios of perfusate [lactate]/[pyruvate] and decreased ratios of perfusate [beta-hydroxybutyrate]/[acetoacetate]. Carbon uptake of Kupffer-cell increased significantly in estriol-treated rats. But these increased uptake were not shown in rats pre-treated by gadolinium chloride blocking phagocytosis. In isolated Kupffer cells from estriol-treated rats, intracellular calcium was more significantly increased after addition of lipopolysaccharide (LPS) than in controls. These findings suggest that the metabolic effects of estriol (two mg per 100 mg body wt) can be summarized to be highly toxic in rat liver, and these findings suggest that oral administration of estrogens may induce hepatic dysfunctions and play a role in the development of liver disease. |
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Authors:
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J M Yang; S S Kim; J I Kim; B M Ahn; S W Choi; J K Kim; C D Lee; K W Chung; H S Sun; D H Park; R G Thurman |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of Korean medical science Volume: 14 ISSN: 1011-8934 ISO Abbreviation: J. Korean Med. Sci. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-09-16 Completed Date: 1999-09-16 Revised Date: 2011-03-16 |
Medline Journal Info:
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Nlm Unique ID: 8703518 Medline TA: J Korean Med Sci Country: KOREA (SOUTH) |
Other Details:
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Languages: eng Pagination: 277-85 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul. jmyang@sph.cuk.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxybutyric Acid
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metabolism Acetoacetates / metabolism Animals Calcium / metabolism Carbohydrate Metabolism Carbon / metabolism Cells, Cultured Colloids / metabolism Estriol / metabolism, pharmacology* Ethanol / pharmacology Female Gadolinium / pharmacology Glucose / biosynthesis Intracellular Fluid / metabolism Kupffer Cells / cytology, metabolism Lactates / metabolism Lipid Metabolism Liver / drug effects*, metabolism Oxygen Consumption Phagocytosis Pyruvic Acid / metabolism Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Acetoacetates; 0/Colloids; 0/Lactates; 10138-52-0/gadolinium chloride; 127-17-3/Pyruvic Acid; 300-85-6/3-Hydroxybutyric Acid; 50-27-1/Estriol; 50-99-7/Glucose; 64-17-5/Ethanol; 7440-44-0/Carbon; 7440-54-2/Gadolinium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Korean Med Sci Journal ID (pmc): jkms ISSN: 1011-8934 ISSN: 1598-6357 Publisher: Korean Academy of Medical Sciences |
Article Information Download PDF  Print publication date: Month: 6 Year: 1999 Volume: 14 Issue: 3 First Page: 277 Last Page: 285 ID: 3054389 PubMed Id: 10402170 |
| The metabolic effects of estriol in female rat liver. | |
| J. M. Yang | Email: jmyang@sph.cuk.ac.kr |
| S. S. Kim | |
| J. I. Kim | |
| B. M. Ahn | |
| S. W. Choi | |
| J. K. Kim | |
| C. D. Lee | |
| K. W. Chung | |
| H. S. Sun | |
| D. H. Park | |
| R. G. Thurman | |
| Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul. |
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