Document Detail

The metabolic consequences of experimental intraventricular hemorrhage.
MedLine Citation:
PMID:  4022375     Owner:  NLM     Status:  MEDLINE    
Experimental intraventricular hemorrhage was produced by injection of autologous fresh blood (0.25 ml/kg) or artificial CSF into the right lateral ventricle of 24 dogs. A transient ventricular fluid acidosis (pH drop to 7.09) was accompanied by increased lactate, pyruvate, ammonia, and Pco2, and decreased bicarbonate and glucose. High lactate/pyruvate ratios were the most persistent abnormality. The control group, which received intraventricular artificial CSF, developed minimal ventricular fluid acidosis (pH 7.26). Lumbar CSF and venous blood acid-base parameters did not change. Simultaneous cisternal samples obtained from some of the animals reflected similar metabolic abnormalities of lesser magnitude. Intraventricular injection of sodium bicarbonate normalized the pH in four animals.
M R Pranzatelli; D A Stumpf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  35     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-09-26     Completed Date:  1985-09-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1299-303     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Physiological Phenomena
Cerebral Hemorrhage / metabolism*
Cerebral Ventricles / metabolism*
Cerebrospinal Fluid / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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