Document Detail

A metabolic comparison of a pure long-chain triglyceride lipid emulsion (LCT) and various medium-chain triglyceride (MCT)-LCT combination emulsions in dogs.
MedLine Citation:
PMID:  3107368     Owner:  NLM     Status:  MEDLINE    
Two 20% lipid emulsions containing mixtures of long-(LCT) and medium-chain triglycerides (MCT) were compared with a 20% LCT lipid emulsion. Beagles were infused with emulsions containing either 100% LCT, 75% LCT-25% MCT, or 50% LCT-50% MCT. The emulsions were part of a total parenteral nutrition (TPN) regimen that included 10% dextrose and 5.5% amino acids. Basic nutritional parameters as well as elimination kinetics were monitored. Plasma linoleic acid, ketone, lactate, pyruvate, insulin, glucose, and carnitine were analyzed. The 75% LCT-25% MCT emulsion offers little advantage over 100% LCT as a metabolic substrate. The 50% LCT-50% MCT combination proved to be a potentially better caloric source due to rapid elimination kinetics, increased ketone production, lack of deposition, and no interference with linoleic acid metabolism.
R Cotter; C A Taylor; R Johnson; W B Rowe
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  45     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-09     Completed Date:  1987-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  927-39     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Glucose / metabolism
Fat Emulsions, Intravenous / metabolism*
Fatty Acids, Nonesterified / metabolism
Insulin / blood
Ketone Bodies / blood
Metabolic Clearance Rate
Parenteral Nutrition, Total
Triglycerides / administration & dosage,  metabolism*
Reg. No./Substance:
0/Blood Glucose; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; 0/Ketone Bodies; 0/Triglycerides; 11061-68-0/Insulin

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