Document Detail

A metabolic approach to the evaluation of peripheral vascular disease.
MedLine Citation:
PMID:  12579     Owner:  NLM     Status:  MEDLINE    
Thirty-five patients with occlusive disease of the arteries underwent metabolic studies. The arteriovenous differences of lactate, glucose and oxygen varied with the severity of the ischemic process, as assessed clinically. Lactate release and glucose extraction were significantly different from control values of patients with rest pain or with ischemic gangrene, while values in patients with claudication were comparable with those in the control group. Percutaneous muscle surface pH measurements, which reflect lactate release, decreased directly with diminished perfusion. Metabolic assessment of arterial occlusive disease may prove to be a useful clinical approach.
T F O'Donnel; G H Clowes; N L Browse; N T Ryan; G L Blackburn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  144     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-02-26     Completed Date:  1977-02-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-7     Citation Subset:  AIM; IM    
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MeSH Terms
Arterial Occlusive Diseases / metabolism*
Gangrene / metabolism
Glucose / metabolism
Hydrogen-Ion Concentration
Ischemia / metabolism
Lactates / metabolism
Leg / blood supply*
Middle Aged
Muscles / metabolism*
Oxygen Consumption
Reg. No./Substance:
0/Lactates; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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