Document Detail


A meta-analytic review of polyunsaturated fatty acid compositions in dementia.
MedLine Citation:
PMID:  22938939     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether the levels of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), arachidonic acid (AA), total n-3 polyunsaturated fatty acids (PUFAs), and total n-6 PUFAs were changed in patients with dementia or predementia syndrome. DATA SOURCES: PubMed was searched for studies from first date available to July 2011 using the following search terms: (dementia OR cognitive impairment OR mild cognitive impairment) AND (omega-3 OR omega-6 OR polyunsaturated fatty acid OR docosahexaenoic acid OR DHA OR eicosapentaenoic acid OR EPA). The search was limited to literature in English and to human studies. The references of relevant articles and review articles were searched for citations not indexed in PubMed. STUDY SELECTION: Studies were included if they measured levels of EPA, DHA, AA, total n-3 PUFAs, or total n-6 PUFAs from peripheral blood tissues in subjects with cognitive deficits (dementia or predementia syndrome) and elderly controls and were published in peer-reviewed journals. The search yielded 10 articles including 2,280 subjects. DATA EXTRACTION: The study design, sample size, PUFA levels for both patients and control subjects, sampling tissue, diagnoses and diagnostic criteria for cognitive deficits, and distribution of mean age and gender of included subjects were extracted for each study. RESULTS: In a random-effects model, we found that the levels of EPA (effect size [ES] = -0.47, P < .0001), DHA (ES = -0.33, P = .017), and total n-3 PUFAs (ES = -0.46, P = .001) were decreased in patients with dementia. However, the levels of EPA (ES = -0.44, P = .002), but not DHA or other PUFAs, were significantly lower in patients with predementia syndrome. CONCLUSIONS: Our results support the important role of n-3 PUFAs in the pathophysiology of dementia. In addition, the analyses of predementia studies indicate that EPA might be not only a disease-state marker but also a risk factor for cognitive impairment.
Authors:
Pao-Yen Lin; Chih-Chiang Chiu; Shih-Yi Huang; Kuan-Pin Su
Related Documents :
2986039 - Pharmacology of the corticocaudate excitatory postsynaptic potential in the cat: eviden...
3691639 - Attenuation of cerebral glucose use in kainic acid-treated rats by diazepam.
22301059 - Mouse sglt3a generates proton-activated currents but does not transport sugar.
17573079 - The kynurenic acid hypothesis of schizophrenia.
2894999 - The pharmacological selectivity of three nmda antagonists.
19268309 - The role of kynurenines in disorders of the central nervous system: possibilities for n...
21691099 - Pleiotropic functions of the organic solute transporter ostα-ostβ.
16661279 - Biological activities of indoleacetylamino acids and their use as auxins in tissue cult...
21869929 - Dietary conjugated linoleic acid and hepatic steatosis: species-specific effects on liv...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-7
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  -     ISSN:  1555-2101     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Copyright 2012 Physicians Postgraduate Press, Inc.
Affiliation:
Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Experimental infection of laboratory mice with two Bartonella tribocorum strains from wild Mus speci...
Next Document:  ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus ...