| A meta-analysis of the use of amoxycillin-clavulanic acid in surgical prophylaxis. | |
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MedLine Citation:
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PMID: 1362755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of amoxycillin-clavulanic acid as antibiotic prophylaxis in surgery has been assessed in numerous clinical studies, chiefly in abdominal and gynaecological surgery. A meta-analysis of 21 trials covering 2685 patients given amoxycillin-clavulanic acid and 2220 patients given comparator regimens is presented. Monotherapy with amoxycillin-clavulanic acid was as effective as the comparators, including combination regimens utilizing gentamicin or metronidazole, in preventing wound infections (median wound infection rates were 6% and 10% respectively). The antibacterial activity of amoxycillin-clavulanic acid covers the broad range of aerobic Gram-negative and anaerobic organisms that have a major role in postoperative infections. In addition, amoxycillin-clavulanic acid may have benefits in terms of convenience, tolerance and cost. |
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Authors:
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A P Wilson; S Shrimpton; M Jaderberg |
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Publication Detail:
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Type: Comparative Study; Journal Article; Meta-Analysis |
Journal Detail:
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Title: The Journal of hospital infection Volume: 22 Suppl A ISSN: 0195-6701 ISO Abbreviation: J. Hosp. Infect. Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1993-03-02 Completed Date: 1993-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007166 Medline TA: J Hosp Infect Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 9-21 Citation Subset: IM |
Affiliation:
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Department of Clinical Microbiology, University College Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen
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microbiology,
surgery Amoxicillin / therapeutic use* Amoxicillin-Potassium Clavulanate Combination Bacterial Infections / prevention & control* Clavulanic Acids / therapeutic use* Double-Blind Method Drug Therapy, Combination / therapeutic use Female Genitalia, Female / microbiology, surgery Humans Surgical Wound Infection / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Clavulanic Acids; 26787-78-0/Amoxicillin; 74469-00-4/Amoxicillin-Potassium Clavulanate Combination |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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