| A meta-analysis of randomized trials on clinical outcomes of paclitaxel-eluting stents versus bare-metal stents in ST-segment elevation myocardial infarction patients. | |
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MedLine Citation:
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PMID: 20872982 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A meta-analysis was performed to address the efficacy and safety of paclitaxel-eluting stent (PES) in ST-segment elevation myocardial infarction (STEMI) patients. A systematic literature search was conducted to identify all randomized clinical trials in mortality, recurrent myocardial infarction (rMI), repeat revascularization (RR), and stent thrombosis (ST). A total of 4190 STEMI patients were enrolled in six randomized trials comparing PES with bare-metal stent (BMS). The pooled repeat revascularization rate was 5.7% in PES group, significantly lower than 10.0% in BMS group with an odds ratio (OR) of 0.56, 95% confidence interval (CI) [0.44, 0.72] (P<0.00001). No significant difference was found between PES and BMS groups in mortality at one year after the indexing procedure (3.9% vs. 5.1%, OR 0.88, 95% CI [0.63, 1.21], P=0.42). Similarly, rMI rate did not differ significantly between the two groups (3.4% vs. 4.1%, OR 0.80, 95% CI [0.56, 1.13], P=0.21). PES was also associated with the comparable pooled rate of definite stent thrombosis with BMS (2.3% vs. 2.4%, OR 0.81, 95% CI [0.52, 1.26], P=0.35). The results show that PES improved clinical outcomes in STEMI patients with a decreased need for repeat revascularization and no concerns for safety. |
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Authors:
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Xiao-hong Pan; Ying-xue Chen; Mei-xiang Xiang; Geng Xu; Jian-an Wang |
Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: Journal of Zhejiang University. Science. B Volume: 11 ISSN: 1862-1783 ISO Abbreviation: J Zhejiang Univ Sci B Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-21 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 101236535 Medline TA: J Zhejiang Univ Sci B Country: China |
Other Details:
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Languages: eng Pagination: 754-61 Citation Subset: IM |
Affiliation:
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Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Balloon, Coronary* Antineoplastic Agents, Phytogenic / administration & dosage* Drug-Eluting Stents* Electrocardiography Humans Myocardial Infarction / therapy* Paclitaxel / administration & dosage* Randomized Controlled Trials as Topic Stents* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 33069-62-4/Paclitaxel |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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