Document Detail

A meta-analysis of left ventricular dyssynchrony assessment and prediction of response to cardiac resynchronization therapy by three-dimensional echocardiography.
MedLine Citation:
PMID:  22379129     Owner:  NLM     Status:  Publisher    
AIMS: In a time of controversy regarding the use of echocardiography for assessment of left ventricular (LV) dyssynchrony and prediction of response to cardiac resynchronization therapy (CRT), this meta-analysis aimed to evaluate the feasibility and reliability of LV dyssynchrony assessment by three-dimensional echocardiography (3DE), determine clinically useful reference values in healthy subjects and heart failure patients, and examine the accuracy of 3DE to predict response to CRT. METHODS AND RESULTS: A total of 73 studies that evaluated the assessment of LV dyssynchrony by 3DE were eligible. The systolic dyssynchrony index (SDI) for 16 segments, being the predominant 3DE dyssynchrony parameter, was used for data pooling. Results demonstrated that LV dyssynchrony assessment by 3DE is feasible in 94% of studied subjects [95% confidence interval (CI): 92-95%)]. Pooled estimates of intraclass correlation coefficients (ICC) and limits of agreement (LoA) demonstrated that SDI has good interobserver (ICC: 0.92, LoA: 4.07%) and intraobserver reliability (ICC: 0.95, LoA: 2.10%). Reference values of SDI in healthy subjects, heart failure patients in general, and patients eligible for CRT were 2.7 ± 0.9%, 9.8 ± 3.9%, and 10.7 ± 3.6%, respectively. Meta-regression analysis demonstrated that reference values of SDI in healthy subjects significantly differed between different software [1.80% (95% CI: 0.55-3.05%), P< 0.001]. In patients eligible for CRT, SDI had good accuracy to predict treatment response with a weighted mean cut-off value of 9.8% and pooled estimates for sensitivity and specificity of 93% (95% CI: 89-97%) and 75% (95% CI: 58-93%), respectively. CONCLUSION: 3DE is a feasible and reliable tool for assessment of LV dyssynchrony and may have additional value to current selection criteria for accurate prediction of response to CRT.
Sebastiaan A Kleijn; Mohamed Fa Aly; Dirk L Knol; Caroline B Terwee; Elise P Jansma; Yasser A Abd El-Hady; Hossam I Kandil; Khalid A Sorour; Albert C van Rossum; Otto Kamp
Related Documents :
3717019 - Two-dimensional echocardiographic demonstration of restoration of normal wall motion af...
17011829 - Analysis of myocardial perfusion or myocardial function for detection of regional myoca...
8223729 - Radionuclide assessment of regional differences in left ventricular wall motion and myo...
7587419 - The heart in sickle cell anemia. the cooperative study of sickle cell disease (csscd).
19377189 - The clockwise rotation of myocardial fiber orientation from epicardial to endocardial s...
2650919 - Relation between longitudinal, circumferential, and oblique shortening and torsional de...
17462339 - Controlled cardiac reoxygenation does not improve myocardial function following global ...
11282889 - Dobutamine-stress magnetic resonance microimaging in mice : acute changes of cardiac ge...
23856219 - Partial mechanical circulatory support in an ovine model of post-infarction remodeling.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-28
Journal Detail:
Title:  European heart journal cardiovascular Imaging     Volume:  -     ISSN:  2047-2412     ISO Abbreviation:  Eur Heart J Cardiovasc Imaging     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-3-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101573788     Medline TA:  Eur Heart J Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Cardiology, and Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Persistent dysfunction of viable myocardium after revascularization in chronic ischaemic heart disea...
Next Document:  Effects of enamel deproteinization on bracket bonding with conventional and resin-modified glass ion...