Document Detail

A meta-analysis of homovanillic acid concentrations in schizophrenia.
MedLine Citation:
PMID:  8132411     Owner:  NLM     Status:  MEDLINE    
The results of several experiments in which homovanillic acid (HVA) concentrations were measured, mainly in the cerebrospinal fluid, of schizophrenics are examined using Fisher's combination procedure. It is found that the data does not support the claim that the level of this dopamine catabolite is raised whereas some evidence strongly supports the claim that it is actually lowered. This finding is discussed in relation to the hypothesis of dopaminergic neuronal hyperactivity in schizophrenia.
H C Tuckwell; J A Koziol
Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  73     ISSN:  0020-7454     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-04-19     Completed Date:  1994-04-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  IM    
Institute of Advanced Studies, Australian National University, Canberra, ACT.
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MeSH Terms
Dopamine / cerebrospinal fluid,  metabolism
Homovanillic Acid / cerebrospinal fluid,  metabolism*
Schizophrenia / cerebrospinal fluid,  metabolism*
Reg. No./Substance:
306-08-1/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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