| A meta-analysis of the effect of angiotensin-converting enzyme inhibitors on functional capacity in patients with symptomatic left ventricular systolic dysfunction. | |
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MedLine Citation:
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PMID: 15556055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To determine by meta-analysis whether angiotensin-converting enzyme (ACE) inhibitors improve exercise tolerance in patients with symptomatic left ventricular systolic dysfunction (LVSD). METHODS AND RESULTS: After literature search 13 multi-centre double blind parallel group trials that evaluated the effect of ACE inhibitors vs. placebo on exercise duration were selected. Ninety-four percent of patients were in New York Heart Association class II-IV. The studies were combined using the Cochrane meta-analysis program (Review manager version 4.1). Analyses according to treatment period, exercise protocols and publication periods were performed. Treatment with ACE inhibitor over 4-12 weeks resulted in a beneficial effect on exercise duration (P=0.003 and P=0.0008 for 4- and 12-weeks treatment, respectively), but the magnitude of improvements did not exceed 30 s corresponding to only 5% compared with placebo. CONCLUSION: In addition to the pronounced effect on mortality and morbidity in patients with symptomatic LVSD, ACE inhibitors have improving effect on functional capacity measured as exercise tolerance time. |
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Authors:
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Jawdat Abdulla; Steen Z Abildstrom; Erik Christensen; Lars Kober; Christian Torp-Pedersen |
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Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: European journal of heart failure Volume: 6 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-23 Completed Date: 2006-05-16 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 927-35 Citation Subset: IM |
Affiliation:
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Department of Cardiology P, Gentofte University Hospital, Niels Andersensvej 65, DK-2990 Hellerup, Denmark. jawab@dadlnet.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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therapeutic use* Clinical Trials as Topic Double-Blind Method Exercise Tolerance / drug effects* Heart Failure / drug therapy, mortality, physiopathology Humans Multicenter Studies as Topic Research Design Systole / drug effects Treatment Outcome Ventricular Dysfunction, Left / drug therapy*, mortality, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors |
| Comments/Corrections | |
Comment In:
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Evid Based Cardiovasc Med. 2005 Jun;9(2):117-9
[PMID:
16380006
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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