Document Detail

A meta-analysis of the effect of angiotensin-converting enzyme inhibitors on functional capacity in patients with symptomatic left ventricular systolic dysfunction.
MedLine Citation:
PMID:  15556055     Owner:  NLM     Status:  MEDLINE    
AIM: To determine by meta-analysis whether angiotensin-converting enzyme (ACE) inhibitors improve exercise tolerance in patients with symptomatic left ventricular systolic dysfunction (LVSD).
METHODS AND RESULTS: After literature search 13 multi-centre double blind parallel group trials that evaluated the effect of ACE inhibitors vs. placebo on exercise duration were selected. Ninety-four percent of patients were in New York Heart Association class II-IV. The studies were combined using the Cochrane meta-analysis program (Review manager version 4.1). Analyses according to treatment period, exercise protocols and publication periods were performed. Treatment with ACE inhibitor over 4-12 weeks resulted in a beneficial effect on exercise duration (P=0.003 and P=0.0008 for 4- and 12-weeks treatment, respectively), but the magnitude of improvements did not exceed 30 s corresponding to only 5% compared with placebo.
CONCLUSION: In addition to the pronounced effect on mortality and morbidity in patients with symptomatic LVSD, ACE inhibitors have improving effect on functional capacity measured as exercise tolerance time.
Jawdat Abdulla; Steen Z Abildstrom; Erik Christensen; Lars Kober; Christian Torp-Pedersen
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  European journal of heart failure     Volume:  6     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-23     Completed Date:  2006-05-16     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  927-35     Citation Subset:  IM    
Department of Cardiology P, Gentofte University Hospital, Niels Andersensvej 65, DK-2990 Hellerup, Denmark.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Exercise Tolerance / drug effects*
Heart Failure / drug therapy,  mortality,  physiopathology
Multicenter Studies as Topic
Research Design
Systole / drug effects
Treatment Outcome
Ventricular Dysfunction, Left / drug therapy*,  mortality,  physiopathology*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors
Comment In:
Evid Based Cardiovasc Med. 2005 Jun;9(2):117-9   [PMID:  16380006 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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