| A meta-analysis of cardiopulmonary resuscitation with and without the administration of thrombolytic agents. | |
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MedLine Citation:
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PMID: 16762481 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To pool data on the role of thrombolytic agents in cardiopulmonary resuscitation (CPR) and evaluate the efficacy and safety of thrombolysis. MATERIALS AND METHODS: The clinical studies in MEDLINE database from 1966 to August 2004 that studied the efficacy and safety in CPR with and without treatment with thrombolytic agents were assessed by a meta-analysis performed to evaluate the effect of the treatment. RESULTS: A total of eight papers evaluating the effect of thrombolysis in CPR were identified. This meta-analysis showed that thrombolytic agents significantly improved the rate of return of spontaneous circulation, 24 h survival rate, survival to discharge and long-term neurological function in patients treated with CPR (p < 0.01). However, the patients receiving thrombolysis had a risk of severe bleeding (p < 0.01). CONCLUSION: Thrombolytic agents during CPR can improve the survival rate to discharge and neurological function. |
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Authors:
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Xin Li; Qing-ling Fu; Xiao-li Jing; Yu-jie Li; Hong Zhan; Zhong-fu Ma; Xiao-xing Liao |
Publication Detail:
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Type: Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't Date: 2006-06-09 |
Journal Detail:
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Title: Resuscitation Volume: 70 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-20 Completed Date: 2006-11-20 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
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Languages: eng Pagination: 31-6 Citation Subset: IM |
Affiliation:
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Department of Emergency, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiopulmonary Resuscitation
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methods*,
statistics & numerical data Fibrinolytic Agents / therapeutic use* Heart Arrest / mortality, therapy Humans Prognosis Survival Rate Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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