Document Detail

A meta-analysis of cardiopulmonary resuscitation with and without the administration of thrombolytic agents.
MedLine Citation:
PMID:  16762481     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To pool data on the role of thrombolytic agents in cardiopulmonary resuscitation (CPR) and evaluate the efficacy and safety of thrombolysis. MATERIALS AND METHODS: The clinical studies in MEDLINE database from 1966 to August 2004 that studied the efficacy and safety in CPR with and without treatment with thrombolytic agents were assessed by a meta-analysis performed to evaluate the effect of the treatment. RESULTS: A total of eight papers evaluating the effect of thrombolysis in CPR were identified. This meta-analysis showed that thrombolytic agents significantly improved the rate of return of spontaneous circulation, 24 h survival rate, survival to discharge and long-term neurological function in patients treated with CPR (p < 0.01). However, the patients receiving thrombolysis had a risk of severe bleeding (p < 0.01). CONCLUSION: Thrombolytic agents during CPR can improve the survival rate to discharge and neurological function.
Xin Li; Qing-ling Fu; Xiao-li Jing; Yu-jie Li; Hong Zhan; Zhong-fu Ma; Xiao-xing Liao
Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't     Date:  2006-06-09
Journal Detail:
Title:  Resuscitation     Volume:  70     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-20     Completed Date:  2006-11-20     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
Department of Emergency, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, PR China.
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MeSH Terms
Cardiopulmonary Resuscitation / methods*,  statistics & numerical data
Fibrinolytic Agents / therapeutic use*
Heart Arrest / mortality,  therapy
Survival Rate
Treatment Outcome
Reg. No./Substance:
0/Fibrinolytic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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