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A meta-analysis on alcohol drinking and the risk of Hodgkin lymphoma.
MedLine Citation:
PMID:  22465910     Owner:  NLM     Status:  Publisher    
The role of alcohol intake in the risk of Hodgkin lymphoma (HL) is still largely unclear. To summarize the evidence on the issue, we carried out a meta-analysis of the available studies. We identified eight case-control and two cohort studies, including a total of 1488 cases of HL. We derived meta-analytic estimates using random-effects models, taking into account the correlation between estimates, and carried out a dose-risk analysis using nonlinear random-effects metaregression models. Compared with nondrinkers, the relative risk for alcohol consumers was 0.70 [95% confidence interval (CI), 0.60-0.81] overall, 0.66 (95% CI, 0.56-0.78) among case-control, and 0.92 (95% CI, 0.63-1.33) among cohort studies. Compared with nondrinkers, the pooled relative risks were 0.71 (95% CI, 0.57-0.89) for light (i.e. ≤1 drink/day) and 0.73 (95% CI, 0.60-0.87) for moderate-to-heavy (i.e. >1 drink/day) alcohol drinking. This meta-analysis suggests a favourable effect of alcohol on HL, in the absence, however, of a dose-risk relationship. The inverse association was restricted to - or greater in - case-control as compared with cohort studies. This indicates caution in the interpretation of results.
Irene Tramacere; Claudio Pelucchi; Martina Bonifazi; Vincenzo Bagnardi; Matteo Rota; Rino Bellocco; Lorenza Scotti; Farhad Islami; Giovanni Corrao; Paolo Boffetta; Carlo La Vecchia; Eva Negri
Publication Detail:
Journal Detail:
Title:  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)     Volume:  21     ISSN:  1473-5709     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300837     Medline TA:  Eur J Cancer Prev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  268-273     Citation Subset:  -    
aMario Negri Institute for Pharmacological Research bDepartment of Statistics, University of Milano-Bicocca cDivision of Epidemiology and Biostatistics, European Institute of Oncology dDepartment of Occupational Health, University of Milano, Milan eDepartment of Clinical Medicine and Prevention, Centre of Biostatistics for Clinical Epidemiology, University of Milano-Bicocca, Monza, Italy fDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden gInternational Agency for Research on Cancer hInternational Prevention Research Institute, Lyon, France iDigestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran jThe Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA.
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