| A meta-analysis of (18)FDG-PET-CT, (18)FDG-PET, MRI and bone scintigraphy for diagnosis of bone metastases in patients with lung cancer. | |
| | |
MedLine Citation:
|
PMID: 21354739 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: Lung cancer is the most common cause of cancer related death among both men and women worldwide. The skeleton is the most common site of cancer metastasis. Early detection is crucial for prognosis. To evaluate and compare the capability for bone metastasis assessment of [(18)F] fluoro-2-d-glucose positron emission tomography with computed tomography ((18)FDG-PET-CT), [(18)F] fluoro-2-d-glucose positron emission tomography ((18)FDG-PET), magnetic resonance imaging (MRI) and bone scintigraphy (BS) in lung cancer patients, a meta-analysis is preformed. METHODS: We searched MEDLINE, OVID, EMBASE and the Cochrane Library for studies evaluating diagnosis validity of (18)FDG-PET-CT, (18)FDG-PET, MRI and BS between January 1990 and August 2010. Meta-analysis methods were used to pool sensitivity, specificity, diagnostic odd ratios (DORs) and to construct a summary receiver-operating characteristic curve (SROC). RESULTS: A total of 17 articles (9 (18)FDG-PET-CT studies, 9 (18)FDG-PET studies, 6 MRI studies and 16 BS studies) that included 2940 patients who fulfilled all of the inclusion criteria were considered for inclusion in the analysis. The pooled sensitivity for the detection of bone metastasis in lung cancer using (18)FDG-PET-CT, (18)FDG-PET, MRI and BS were 0.92 (95% CI, 0.88-0.95), 0.87 (95% CI, 0.81-0.92), 0.77 (95% CI, 0.65-0.87) and 0.86 (95% CI, 0.82-0.89), respectively. The pooled specificity for the detection of bone metastasis from lung cancer using (18)FDG-PET-CT, (18)FDG-PET, MRI and BS were 0.98 (95% CI, 0.97-0.98), 0.94 (95% CI, 0.92-0.96), 0.92 (95% CI, 0.88-0.95), 0.88 (95% CI, 0.86-0.89), respectively. The pooled DORs estimates for (18)FDG-PET-CT 449.17 were significantly higher than for (18)FDG-PET (118.25, P<0.001), MRI (38.27, P<0.001) and BS (63.37, P<0.001). The pooled sensitivity of BS was not correlated with the prevalence of bone metastasis. CONCLUSION: The results showed that both (18)FDG-PET-CT and (18)FDG-PET were better imaging methods for diagnosing bone metastasis from lung cancer than MRI and BS. (18)FDG-PET-CT has higher diagnostic value (sensitivity, specificity and DORs) for diagnosing bone metastasis from lung cancer than any other imaging methods. |
| | |
Authors:
|
Xinhua Qu; Xiaolu Huang; Weili Yan; Lianming Wu; Kerong Dai |
Related Documents
:
|
3685359 - Osteochondritis dissecans: analysis of mechanical stability with radiography, scintigra... 18855299 - Osteoblastoma of the temporal bone: a case report. 17541709 - Breast cancer metastasis to bone: evaluation of bioluminescent imaging and microspect/c... 22579529 - 3d-imaging of the knee with an optimized 3d-fse-sequence and a 15-channel knee-coil. 3975659 - Magnetic resonance imaging of bone and soft tissue tumors: early experience in 31 patie... 18697709 - Variation in segmentation of bone from micro-ct imaging: implications for quantitative ... 11071439 - Proton magnetic resonance spectroscopy of a patient with gerstmann-straussler-scheinker... 18355999 - Regional migratory osteoporosis. 3779889 - Magnetic resonance imaging in pediatric hematology/oncology. part i. basic technology. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-25 |
Journal Detail:
|
Title: European journal of radiology Volume: - ISSN: 1872-7727 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, PR China; Engineering Research Center of Digital Medicine, Ministry of Education, PRC, 1954 Huashan Road, Shanghai 200030, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Solitary necrotic nodule of the liver: MR findings in 33 pathologically proved lesions.
Next Document: Intra- and interobserver variability of magnetic resonance imaging for quantitative assessment of ab...