Document Detail

A memory effect in DNA replication.
MedLine Citation:
PMID:  6375735     Owner:  NLM     Status:  MEDLINE    
A study of the polymerization/excision ratio in the replication of poly(dA), primed with oligo(dT), was carried out with E. coli DNA polymerase I, at various primer and enzyme concentrations. The variations in this ratio suggest that 1) the DNA polymerase is able to switch between two states of low and high exonuclease activities and 2) after dissociating from the template, the DNA polymerase drifts towards the low exonuclease state. The recovery of the high exonuclease state would require several successive incorporations.
C Papanicolaou; M Dorizzi; J Ninio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimie     Volume:  66     ISSN:  0300-9084     ISO Abbreviation:  Biochimie     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-08-13     Completed Date:  1984-08-13     Revised Date:  2002-11-01    
Medline Journal Info:
Nlm Unique ID:  1264604     Medline TA:  Biochimie     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  115-9     Citation Subset:  IM    
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MeSH Terms
DNA Polymerase I / metabolism*
DNA Replication*
Escherichia coli / enzymology*,  genetics
Poly A
Templates, Genetic
Reg. No./Substance:
24937-83-5/Poly A; 25191-20-2/poly(dA); EC 2.7.7.-/DNA Polymerase I

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