| A memory effect in DNA replication. | |
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MedLine Citation:
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PMID: 6375735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study of the polymerization/excision ratio in the replication of poly(dA), primed with oligo(dT), was carried out with E. coli DNA polymerase I, at various primer and enzyme concentrations. The variations in this ratio suggest that 1) the DNA polymerase is able to switch between two states of low and high exonuclease activities and 2) after dissociating from the template, the DNA polymerase drifts towards the low exonuclease state. The recovery of the high exonuclease state would require several successive incorporations. |
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Authors:
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C Papanicolaou; M Dorizzi; J Ninio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochimie Volume: 66 ISSN: 0300-9084 ISO Abbreviation: Biochimie Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-08-13 Completed Date: 1984-08-13 Revised Date: 2002-11-01 |
Medline Journal Info:
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Nlm Unique ID: 1264604 Medline TA: Biochimie Country: FRANCE |
Other Details:
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Languages: eng Pagination: 115-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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DNA Polymerase I
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metabolism* DNA Replication* Escherichia coli / enzymology*, genetics Kinetics Poly A Templates, Genetic |
| Chemical | |
Reg. No./Substance:
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24937-83-5/Poly A; 25191-20-2/poly(dA); EC 2.7.7.-/DNA Polymerase I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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