Document Detail

The membrane rupture theory of Menière's disease--is it valid?
MedLine Citation:
PMID:  3374233     Owner:  NLM     Status:  MEDLINE    
The Membrane Rupture Theory states that the acute attack of Menière's disease occurs when endolymph, with its high potassium ion concentration, escapes into the perilymph and surrounds the first-order neuron. Initially, this causes partial depolarization of the nerve and an increased resting discharge, followed by complete depolarization. Clinically, one would expect an initial irritative nystagmus (toward the affected side) followed by a paralytic nystagmus (toward the unaffected side). To confirm this, the guinea pig perilymphatic space was perfused with an artificial endolymph solution. The results confirmed an irritative/paralytic sequence of nystagmus that differs from the pattern of spontaneous nystagmus observed with ENG monitoring during the acute attack of Menière's disease. Early in the attack, one observes a paralytic nystagmus followed by a secondary nystagmus beating toward the affected side (similar to an irritative nystagmus) as the patient recovers. This raises questions about the validity of the Membrane Rupture Theory.
D H Brown; J A McClure; Z Downar-Zapolski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  98     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-06-30     Completed Date:  1988-06-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  599-601     Citation Subset:  IM    
Department of Otolaryngology, University of Western Ontario, London, Canada.
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MeSH Terms
Disease Models, Animal
Ear, Inner / injuries,  physiopathology*
Guinea Pigs
Meniere Disease / etiology*,  physiopathology
Nystagmus, Pathologic / physiopathology
Osmolar Concentration
Perilymph / physiology
Potassium / physiology
Reg. No./Substance:

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