Document Detail

A membrane protein with possible relevance to sexual cell fusion in Dictyostelium discoideum.
MedLine Citation:
PMID:  3208193     Owner:  NLM     Status:  MEDLINE    
The molecular mechanism of sexual cell fusion in Dictyostelium discoideum was studied using the heterothallic strains HM1 and NC4. Monovalent antibodies (Fab) prepared from rabbit antiserum against a crude membrane preparation of fusion-competent HM1 cells inhibited fusion between HM1 and NC4 cells. Six out of 43 antigenic proteins were found in fusion-competent HM1 cells but not in fusion-incompetent cells. Among them, only one protein with a molecular mass of 70 kDa was able to neutralize the fusion-inhibiting activity of Fab, suggesting its possible participation in sexual cell fusion.
H Urushihara; Y Habata; K Yanagisawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell differentiation and development : the official journal of the International Society of Developmental Biologists     Volume:  25     ISSN:  0922-3371     ISO Abbreviation:  Cell Differ. Dev.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1989-02-13     Completed Date:  1989-02-13     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  8811335     Medline TA:  Cell Differ Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  81-7     Citation Subset:  IM    
Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan.
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MeSH Terms
Cell Fusion / drug effects
Dictyostelium / cytology*,  drug effects,  metabolism
Immune Sera / pharmacology
Membrane Proteins / immunology,  pharmacology*
Molecular Weight
Reg. No./Substance:
0/Immune Sera; 0/Membrane Proteins

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