| A membrane antigen (HC1) selectively present on hairy cell leukemia cells, endothelial cells, and epidermal basal cells. | |
| | |
MedLine Citation:
|
PMID: 6609956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A monoclonal antibody (alpha HC1) raised against HCL cells reacted specifically with HCL cells and not with other normal or leukemic B cell types. It also reacted with BC and with vascular EC. One case of Kaposi's sarcoma, a tumor thought to derive from EC, was also stained by this antibody. Sinusoidal cells of liver and spleen and EC in the brain did not stain with alpha HC1, but EC from all other tissues and EC in culture were positive. Because the exact normal cell equivalent of the leukemic hairy cell is unknown, similarities in phenotype and function between EC and hairy cells are of particular interest. |
| | |
Authors:
|
D N Posnett; C C Marboe; D M Knowles; E A Jaffe; H G Kunkel |
Related Documents
:
|
22635056 - Internalized gap junctions are degraded by autophagy. 4109596 - Synthesis and secretion of gammaglobulin by lymph node cells: the acquisition of carboh... 23572256 - Stage-specific embryonic antigen-1 expression by undifferentiated spermatogonia in the ... 23701726 - Pax3 is overexpressed in human glioblastomas and critically regulates the tumorigenicit... 7035576 - Ultrastructure of human cutaneous candidosis. 17717696 - Local origin and activity-dependent generation of nestin-expressing protoplasmic astroc... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 132 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 1984 Jun |
Date Detail:
|
Created Date: 1984-06-27 Completed Date: 1984-06-27 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 2700-2 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antibodies, Monoclonal
/
diagnostic use Antigens, Neoplasm / analysis*, immunology Antigens, Surface / analysis*, immunology B-Lymphocytes / immunology Capillaries / immunology Endothelium / immunology* Epidermis / immunology* Humans Leukemia, Hairy Cell / immunology* Lymphoid Tissue / immunology Umbilical Veins |
| Grant Support | |
ID/Acronym/Agency:
|
1R23CA 35463-01/CA/NCI NIH HHS; HL 18228/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Monoclonal; 0/Antigens, Neoplasm; 0/Antigens, Surface |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antigen-stimulated human B cell clones are committed to the production of a single class of antibody...
Next Document: Demonstration of activation-specific interactions among B lymphocyte membrane proteins by a photorea...