Document Detail

The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats.
MedLine Citation:
PMID:  15350695     Owner:  NLM     Status:  MEDLINE    
Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.
Ryouichi Banno; Hiroshi Arima; Ikuko Sato; Masayuki Hayashi; Motomitsu Goto; Yoshihisa Sugimura; Takashi Murase; Yutaka Oiso
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peptides     Volume:  25     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-07     Completed Date:  2005-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1279-86     Citation Subset:  IM    
Department of Metabolic Diseases, Field of Internal Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
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MeSH Terms
Adipose Tissue / metabolism
Body Weight / drug effects
Eating / drug effects
Glucose Tolerance Test
Homeostasis / physiology
Insulin Resistance / physiology*
Models, Biological
Peptides, Cyclic / pharmacology*
Rats, Inbred OLETF
Time Factors
Triglycerides / blood
alpha-MSH / agonists*,  analogs & derivatives*,  pharmacology*
Reg. No./Substance:
0/Peptides, Cyclic; 0/Triglycerides; 121062-08-6/melanotan-II; 581-05-5/alpha-MSH

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