| The meiotic differentiation program uncouples S-phase from cell size control in Saccharomyces cerevisiae. | |
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MedLine Citation:
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PMID: 18245950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell size homeostasis in proliferating cell populations is maintained in part by linking the initiation of a cell division cycle to growth such that a specific "size threshold" must be achieved prior to cell cycle initiation. In Saccharomyces cerevisiae the size threshold is responsive to environmental conditions and cell cycle entry is initiated at smaller sizes in poor growth medium and larger sizes in rich medium. In response to starvation for nitrogen and glucose diploid S. cerevisiae abandon proliferation and initiate gametogenesis (sporulation). The ability of both small and large cells to sporulate was investigated and the data reported here indicate that very small S. cerevisiae cells derived from the SK1 genetic background are able to sporulate. Although larger cells progress through the process more rapidly than small cells, sporulation of very small cells appears to be normal as they undergo meiotic recombination and form viable spores. Genetic analysis indicates that this trait is determined by multiple genes and may explain why some S. cerevisiae strains appear to display a minimal size threshold for sporulation. These data support a model where cell size controls can be bypassed or profoundly altered specifically to allow cellular differentiation in response to environmental signals. |
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Authors:
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David Stuart |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-03 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 7 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-04-21 Completed Date: 2008-09-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 777-86 Citation Subset: IM |
Affiliation:
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University of Alberta, Department of Biochemistry, Edmonton, Alberta, Canada. dtstuart@gpu.srv.ualberta.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Differentiation
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physiology* Cell Proliferation* Crosses, Genetic Flow Cytometry Models, Biological* S Phase / physiology* Saccharomyces cerevisiae / cytology*, genetics, growth & development* Spores, Fungal / genetics, physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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