| The medullary dorsal horn: a target for the expression of opiate effects on the perceived intensity of noxious heat. | |
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MedLine Citation:
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PMID: 3760950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effects of morphine microinjected into the medullary dorsal horn (MDH) on the ability of monkeys to detect temperature increases in the noxious heat range. Behavioral detection latency and the percentage of correct detections were used as measures of the perceived intensity of noxious heat stimuli. Three monkeys were trained to detect a change (T2) of 0.4, 0.6, or 1.0 degrees C from a previous noxious heat level of 46 degrees C (T1). Effects on attentional, motivational, and motoric aspects of the monkeys' behavior were assessed by having them detect innocuous cooling and visual stimuli in tasks of similar difficulty. Morphine (1, 3, and 10 micrograms) microinjected into the MDH produced a dose-dependent and stimulus-intensity-dependent increase in the latency to detection of the T2 stimuli. These effects were opiate receptor-mediated since they were antagonized by systemically administered naloxone (0.5 mg/kg, i.m.) given 40 min after the microinjection of morphine. There were no effects of morphine on the behavioral detection latencies to the innocuous cooling and visual stimuli, indicating that the effects of morphine were modality-specific and independent of changes in motivation, attention, or motoric ability. These data demonstrate a pharmacologically specific effect of opiates on the perceived intensity of noxious heat stimuli at the earliest central relay pathway transmitting noxious information. |
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Authors:
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J L Oliveras; W Maixner; R Dubner; M C Bushnell; D R Kenshalo; G H Duncan; D A Thomas; R Bates |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 6 ISSN: 0270-6474 ISO Abbreviation: J. Neurosci. Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1986-11-12 Completed Date: 1986-11-12 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3086-93 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects Dose-Response Relationship, Drug Macaca fascicularis Macaca mulatta Medulla Oblongata / physiology* Microinjections Morphine / pharmacology Naloxone / pharmacology Narcotics / pharmacology* Pruritus / chemically induced, physiopathology Spinal Cord / physiology* Temperature Sense / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Narcotics; 465-65-6/Naloxone; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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