Document Detail

The medial hypothalamus is required for the feeding response to glucoprivation but not to food deprivation.
MedLine Citation:
PMID:  19664685     Owner:  NLM     Status:  MEDLINE    
While the hypothalamus has been implicated in the regulation of energy balance, the central mechanisms and neural circuit that coordinate the feeding response to energy deficit have not been fully clarified. To better understand the role of the hypothalamus in mediating hyperphagic responses to food deprivation or glucoprivation, we examined the feeding responses in rats in which the medial hypothalamus (MH) was isolated from the rest of the brain. The isolation of the MH was performed with a Halasz's knife cut, and experiments were performed 7 days after the operation. Food consumption between 9:00 a.m. and 11:00 a.m. in rats which had been fasted overnight was significantly increased compared to that in rats which had access to food ad libitum before the measurement in both the sham and MH-isolated groups, and the absolute values of food consumption in fasted rats were not significantly different between the groups. On the other hand, while an injection of 2-deoxy-d-glucose, which blocks glucose utilization, significantly increased food consumption for 2h after injection compared to a saline injection in the sham group, it did not increase food intake compared to saline injection in the MH-isolated groups. Thus, it is demonstrated that glucoprivation is not an effective stimulus to induce feeding in MH-isolated rats.
Minemori Watanabe; Hiroshi Arima; Yoshiharu Ozawa; Motomitsu Goto; Hiroshi Shimizu; Ryoichi Banno; Yoshihisa Sugimura; Nobuaki Ozaki; Hiroshi Nagasaki; Yutaka Oiso
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Publication Detail:
Type:  Journal Article     Date:  2009-08-05
Journal Detail:
Title:  Neuroscience letters     Volume:  464     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-08-31     Completed Date:  2009-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  6-9     Citation Subset:  IM    
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
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MeSH Terms
Deoxyglucose / pharmacology
Feeding Behavior*
Food Deprivation*
Glucose / deficiency*
Hyperphagia / physiopathology
Hypothalamus, Middle / physiology*
Rats, Sprague-Dawley
Reg. No./Substance:
154-17-6/Deoxyglucose; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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