Document Detail


The medial cochlear efferent system does not appear to contribute to the development of acquired resistance to acoustic trauma.
MedLine Citation:
PMID:  9667438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Noise-induced hearing loss (NIHL) was compared between sound conditioned and unconditioned guinea pigs, in which the left ear in both groups had been perfused with strychnine. Animals in the conditioned group were subjected to moderate sound (85 dB SPL broadband, 5 h/day, 10 days) and then exposed to intense sound (110 dB SPL broadband, 5 h). Unconditioned animals were exposed only to the intense sound. Following intense sound exposure, strychnine-treated ears showed greater NIHL than untreated ears in both unconditioned and conditioned animals, demonstrating the role of the medial efferents to reduce NIHL. Conditioned animals, however, showed smaller hearing loss and cochlear damage in both strychnine-treated and untreated ears compared to unconditioned animals; the protective effects given by conditioning were equivalent between the strychnine-treated and untreated ears. These results suggest that, although the medial efferent system acts to attenuate NIHL, it may not be necessary for the acquired resistance to NIHL provided by conditioning.
Authors:
T Yamasoba; D F Dolan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hearing research     Volume:  120     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-09-17     Completed Date:  1998-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  143-51     Citation Subset:  IM    
Affiliation:
Kresge Hearing Research Institute, The University of Michigan, Ann Arbor 48109-0506, USA.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Auditory Threshold / drug effects,  physiology
Cochlea / drug effects,  innervation*,  physiopathology
Female
Guinea Pigs
Hearing Loss, Noise-Induced / physiopathology*
Humans
Middle Aged
Neurons, Efferent / drug effects,  physiology*
Perfusion
Strychnine
Grant Support
ID/Acronym/Agency:
DC 00078/DC/NIDCD NIH HHS; DC 00141/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
57-24-9/Strychnine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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