Document Detail


A mechanosensory pathway to the Drosophila circadian clock.
MedLine Citation:
PMID:  24482478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Circadian clocks attune the physiology of virtually all living organisms to the diurnal cycles of their environments. In metazoan animals, multiple sensory input pathways have been linked to clock synchronization with the environmental cycle (entrainment). Extrinsic entrainment cues include light and temperature. We show that (12-hour:12-hour) cycles of vibration and silence (VS) are sufficient to synchronize the daily locomotor activity of wild-type Drosophila melanogaster. Behavioral synchronization to VS cycles required a functional clock and functional chordotonal organs and was accompanied by phase-shifts of the daily oscillations of PERIOD protein concentrations in brain clock neurons. The feedback from mechanosensory-and particularly, proprioceptive-organs may help an animal to keep its circadian clock in sync with its own, stimulus-induced activities.
Authors:
Alekos Simoni; Werner Wolfgang; Matthew P Topping; Ryan G Kavlie; Ralf Stanewsky; Joerg T Albert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  343     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-01-31     Completed Date:  2014-02-24     Revised Date:  2014-06-11    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  525-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Behavior, Animal / physiology*
Brain / cytology,  metabolism
Circadian Clocks*
Cues
Drosophila Proteins / metabolism
Drosophila melanogaster / physiology*
Mechanotransduction, Cellular*
Motor Activity / physiology*
Neurons / metabolism
Period Circadian Proteins / metabolism
Proprioception*
Sound
Vibration
Grant Support
ID/Acronym/Agency:
BB/G004455/1//Biotechnology and Biological Sciences Research Council; BB/H001204/1//Biotechnology and Biological Sciences Research Council
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/PER protein, Drosophila; 0/Period Circadian Proteins
Comments/Corrections
Comment In:
Cell Metab. 2014 May 6;19(5):739-40   [PMID:  24807220 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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