Document Detail


A mechanobiological model of orthodontic tooth movement.
MedLine Citation:
PMID:  22539046     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Orthodontic tooth movement is achieved by the process of repeated alveolar bone resorption on the pressure side and new bone formation on the tension side. In order to optimize orthodontic treatment, it is important to identify and study the biological processes involved. This article presents a mechanobiological model using partial differential equations to describe cell densities, growth factor concentrations, and matrix densities occurring during orthodontic tooth movement. We hypothesize that such a model can predict tooth movement based on the mechanobiological activity of cells in the PDL. The developed model consists of nine coupled non-linear partial differential equations, and two distinct signaling pathways were modeled: the RANKL-RANK-OPG pathway regulating the communication between osteoblasts and osteoclasts and the TGF-β pathway mediating the differentiation of mesenchymal stem cells into osteoblasts. The predicted concentrations and densities were qualitatively validated by comparing the results to experiments reported in the literature. In the current form, the model supports our hypothesis, as it is capable of conceptually simulating important features of the biological interactions in the alveolar bone-PDL complex during orthodontic tooth movement.
Authors:
A Van Schepdael; J Vander Sloten; L Geris
Related Documents :
1770856 - Hierarchical distribution analysis for computer-assisted classifications of patient rec...
12450096 - Comparisons between exemplar similarity and mixed prototype models using a linearly sep...
19502126 - Managing category proliferation in fuzzy artmap caused by overlapping classes.
16602136 - Selection and combination of machine learning classifiers for prediction of linear b-ce...
2367546 - Theoretical and experimental comparison of three types of electromagnetic hyperthermia ...
25368506 - Quality control for rna-seq (quacrs): an integrated quality control pipeline.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-27
Journal Detail:
Title:  Biomechanics and modeling in mechanobiology     Volume:  -     ISSN:  1617-7940     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135325     Medline TA:  Biomech Model Mechanobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Biomechanics Section, KU Leuven, Celestijnenlaan 300C, Box 2419, 3001, Heverlee, Belgium, an.vanschepdael@mech.kuleuven.be.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Missed lesions at CT colonography: lessons learned.
Next Document:  A Facile Route to Boronic Acid Functional Polymeric Microspheres via Epoxide Ring Opening.