| A mechanobiological model of orthodontic tooth movement. | |
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MedLine Citation:
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PMID: 22539046 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Orthodontic tooth movement is achieved by the process of repeated alveolar bone resorption on the pressure side and new bone formation on the tension side. In order to optimize orthodontic treatment, it is important to identify and study the biological processes involved. This article presents a mechanobiological model using partial differential equations to describe cell densities, growth factor concentrations, and matrix densities occurring during orthodontic tooth movement. We hypothesize that such a model can predict tooth movement based on the mechanobiological activity of cells in the PDL. The developed model consists of nine coupled non-linear partial differential equations, and two distinct signaling pathways were modeled: the RANKL-RANK-OPG pathway regulating the communication between osteoblasts and osteoclasts and the TGF-β pathway mediating the differentiation of mesenchymal stem cells into osteoblasts. The predicted concentrations and densities were qualitatively validated by comparing the results to experiments reported in the literature. In the current form, the model supports our hypothesis, as it is capable of conceptually simulating important features of the biological interactions in the alveolar bone-PDL complex during orthodontic tooth movement. |
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Authors:
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A Van Schepdael; J Vander Sloten; L Geris |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-27 |
Journal Detail:
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Title: Biomechanics and modeling in mechanobiology Volume: - ISSN: 1617-7940 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135325 Medline TA: Biomech Model Mechanobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Biomechanics Section, KU Leuven, Celestijnenlaan 300C, Box 2419, 3001, Heverlee, Belgium, an.vanschepdael@mech.kuleuven.be. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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