| A mechanistic explanation for pH-dependent ambient aquatic toxicity of Prymnesium parvum carter. | |
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MedLine Citation:
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PMID: 19799926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The harmful algal bloom species Prymnesium parvum has caused millions of dollars in damage to fisheries around the world. These fish kills have been attributed to P. parvum releasing a mixture of toxins in the water. The characterized toxins, reported as prymnesin-1 and -2, have structural similarities consistent with other known ionizable compounds (e.g., ammonia). We investigated whether pH affects the toxicity of P. parvum under conditions representative of inland Texas reservoirs experiencing ambient toxicity from bloom formation. We evaluated pH influences on toxicity in laboratory and field samples, and modeled the physicochemical properties of prymnesins. Aquatic toxicity to a model fish and cladoceran was reduced by lowering pH in samples obtained from reservoirs experiencing P. parvum blooms; similar observations were confirmed for experiments with laboratory cultures. A pKa value of 8.9 was predicted for the prymnesins, which suggests that ionization states of these toxins may change appreciably over surface water pH of inland waters. These findings indicate that ionization states of toxins released by P. parvum may strongly influence site-specific toxicity and subsequent impacts to fisheries. Consequently, these results emphasize the importance of understanding processes that affect pH during P. parvum blooms, which may improve predictions of ambient toxicity. |
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Authors:
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Theodore W Valenti; Susan V James; Mieke J Lahousse; Kevin A Schug; Daniel L Roelke; James P Grover; Bryan W Brooks |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-09-30 |
Journal Detail:
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Title: Toxicon : official journal of the International Society on Toxinology Volume: 55 ISSN: 1879-3150 ISO Abbreviation: Toxicon Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-03-12 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1307333 Medline TA: Toxicon Country: England |
Other Details:
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Languages: eng Pagination: 990-8 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Environmental Science and Center for Reservoir and Aquatic Systems Research, Baylor University, One Bear Place #97266, Baylor University, Waco, TX 76798, USA. ted_valenti@baylor.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Toxicity Tests Algae / physiology* Animals Biological Assay Cyprinidae / physiology Daphnia / physiology Harmful Algal Bloom / physiology* Hydrogen-Ion Concentration Larva / drug effects Lethal Dose 50 Lipoproteins / chemistry, toxicity* Longevity / drug effects Marine Toxins / chemistry, toxicity* Models, Chemical Physicochemical Processes Poisons / chemistry, toxicity* Water Pollutants, Chemical / chemistry, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins; 0/Marine Toxins; 0/Poisons; 0/Water Pollutants, Chemical; 11025-94-8/prymnesin |
| Comments/Corrections | |
Comment In:
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Toxicon. 2010 May;55(5):1038-43
[PMID:
20223345
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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