| A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture. | |
| | |
MedLine Citation:
|
PMID: 22777419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The role of microcalcifications (μCalcs) in the biomechanics of vulnerable plaque rupture is examined. Our laboratory previously proposed (Ref. 44), using a very limited tissue sample, that μCalcs embedded in the fibrous cap proper could significantly increase cap instability. This study has been greatly expanded. Ninety-two human coronary arteries containing 62 fibroatheroma were examined using high-resolution microcomputed tomography at 6.7-μm resolution and undecalcified histology with special emphasis on calcified particles <50 μm in diameter. Our results reveal the presence of thousands of μCalcs, the vast majority in lipid pools where they are not dangerous. However, 81 μCalcs were also observed in the fibrous caps of nine of the fibroatheroma. All 81 of these μCalcs were analyzed using three-dimensional finite-element analysis, and the results were used to develop important new clinical criteria for cap stability. These criteria include variation of the Young's modulus of the μCalc and surrounding tissue, μCalc size, and clustering. We found that local tissue stress could be increased fivefold when μCalcs were closely spaced, and the peak circumferential stress in the thinnest nonruptured cap (66 μm) if no μCalcs were present was only 107 kPa, far less than the proposed minimum rupture threshold of 300 kPa. These results and histology suggest that there are numerous μCalcs < 15 μm in the caps, not visible at 6.7-μm resolution, and that our failure to find any nonruptured caps between 30 and 66 μm is a strong indication that many of these caps contained μCalcs. |
| | |
Authors:
|
Natalia Maldonado; Adreanne Kelly-Arnold; Yuliya Vengrenyuk; Damien Laudier; John T Fallon; Renu Virmani; Luis Cardoso; Sheldon Weinbaum |
Related Documents
:
|
18663599 - Narrowing the phase window width in prospectively ecg-gated single heart beat 320-detec... 22149119 - Influence of differing material properties in media and adventitia on arterial adaptati... 21728859 - Characterization of the responses of equine digital veins and arteries to calcitonin ge... 19719499 - Cryoablation at growing myocardium: no evidence of coronary artery obstruction or intim... 21160609 - Contribution of oxidative stress to pulmonary arterial hypertension. 972129 - Automic innervation of dog coronary arteries. 12735599 - Surgical treatment of the left circumflex coronary artery from the pulmonary artery in ... 7708149 - Treatment of experimental aneurysms using collagen-coated microcoils. 14658209 - Gut feeling. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Webcasts Date: 2012-07-09 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: 303 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-09-03 Completed Date: 2012-11-07 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: H619-28 Citation Subset: IM |
Affiliation:
|
Department of Biomedical Engineering, The City College of New York, The City University of New York, New York, New York 10031, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Biomechanics Computer Simulation Coronary Artery Disease / complications, physiopathology, radiography* Coronary Vessels / pathology*, physiopathology Elastic Modulus Female Fibrosis Finite Element Analysis Humans Imaging, Three-Dimensional* Male Middle Aged Models, Cardiovascular Plaque, Atherosclerotic Radiographic Image Interpretation, Computer-Assisted* Rupture, Spontaneous Stress, Mechanical Vascular Calcification / complications, physiopathology, radiography* X-Ray Microtomography / methods* |
| Grant Support | |
ID/Acronym/Agency:
|
AG034198/AG/NIA NIH HHS; RCI HL101151/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acute O-GlcNAcylation prevents inflammation-induced vascular dysfunction.
Next Document: Gene and cytokine therapy for heart failure: molecular mechanisms in the improvement of cardiac func...