Document Detail


The mechanisms of vertebrate light adaptation: speeded recovery versus slowed activation.
MedLine Citation:
PMID:  8794098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Light adaptation in vertebrate photoreceptors is commonly attributed to a feedback mechanism that reduces the amplitude of the receptor potential by speeding the inactivation of the transduction cascade and hastening the recovery process. Recent studies have challenged this model and suggest instead that desensitization originates mainly from changes in the activation phase rather than the recovery phase of the response. This has important implications for understanding the molecular mechanisms that underlie the control of sensitivity in this G-protein-coupled, signal-transduction pathway.
Authors:
P B Detwiler; M P Gray-Keller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in neurobiology     Volume:  6     ISSN:  0959-4388     ISO Abbreviation:  Curr. Opin. Neurobiol.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-12-16     Completed Date:  1996-12-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9111376     Medline TA:  Curr Opin Neurobiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  440-4     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, 98195, USA. detwiler@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Ocular*
Animals
Feedback
GTP-Binding Proteins / physiology
Humans
Signal Transduction
Time Factors
Vertebrates / physiology*
Grant Support
ID/Acronym/Agency:
EY02048/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
EC 3.6.1.-/GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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