| On the mechanisms and clinical relevance of one-kidney, one-clip hypertension. | |
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MedLine Citation:
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PMID: 1741991 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dr. Skeggs demonstrated the lack of renin dependence in 1-kidney, 1-clip hypertension and elucidated some of the differences between that and Dr. Goldblatt's classic 2-kidney, 1-clip model of hypertension. Studies of these two different types of hypertension have led research in many new directions and helped to reveal the role of the renin-angiotensin system in hypertension and that system's interaction with sodium-induced vasodilation in both animals and humans. More recent research has investigated the processes behind essential hypertension and I present here the proposal that, due to nephron heterogeneity, essential hypertension in humans is parallel in its pathophysiologic processes to Goldblatt hypertension. |
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Authors:
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J H Laragh |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of hypertension Volume: 4 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 1991 Oct |
Date Detail:
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Created Date: 1992-01-16 Completed Date: 1992-01-16 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 541S-545S Citation Subset: IM |
Affiliation:
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New York Hospital-Cornell Medical Center, New York City 10021. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Humans Hypertension, Renovascular / physiopathology* Kidney / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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