Document Detail


On the mechanisms and clinical relevance of one-kidney, one-clip hypertension.
MedLine Citation:
PMID:  1741991     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dr. Skeggs demonstrated the lack of renin dependence in 1-kidney, 1-clip hypertension and elucidated some of the differences between that and Dr. Goldblatt's classic 2-kidney, 1-clip model of hypertension. Studies of these two different types of hypertension have led research in many new directions and helped to reveal the role of the renin-angiotensin system in hypertension and that system's interaction with sodium-induced vasodilation in both animals and humans. More recent research has investigated the processes behind essential hypertension and I present here the proposal that, due to nephron heterogeneity, essential hypertension in humans is parallel in its pathophysiologic processes to Goldblatt hypertension.
Authors:
J H Laragh
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of hypertension     Volume:  4     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-01-16     Completed Date:  1992-01-16     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  541S-545S     Citation Subset:  IM    
Affiliation:
New York Hospital-Cornell Medical Center, New York City 10021.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Humans
Hypertension, Renovascular / physiopathology*
Kidney / physiology*

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