Document Detail

The mechanisms of action of nicotinamide and zinc in inflammatory skin disease.
MedLine Citation:
PMID:  16871773     Owner:  NLM     Status:  MEDLINE    
Nicotinamide (niacinamide), a physiologically active form of niacin (nicotinic acid), in combination with zinc is being assessed in clinical studies for the treatment of inflammatory skin diseases such as acne vulgaris and bullous pemphigoid. The basis for these investigations is the variety of potential mechanisms of action of nicotinamide and zinc, including an anti-inflammatory effect via inhibition of leukocyte chemotaxis, lysosomal enzyme release, lymphocytic transformation, mast cell degranulation, bacteriostatic effect against Propionibacterium acnes, inhibition of vasoactive amines, preservation of intracellular coenzyme homeostasis, and decreased sebum production. Other possible mechanisms involve suppression of vascular permeability and inflammatory cell accumulation, as well as protection against DNA damage. The goal of this paper is to review the pathophysiology of inflammatory skin diseases and discuss the role, mechanisms of action, and safety of nicotinamide and zinc as therapeutic options for these disorders.
David P Fivenson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cutis     Volume:  77     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-07-28     Completed Date:  2006-10-16     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5-10     Citation Subset:  IM    
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MeSH Terms
Acne Vulgaris / drug therapy*,  microbiology,  pathology
Anti-Inflammatory Agents / pharmacology*
Drug Combinations
Lipogenesis / drug effects
Molecular Structure
Niacinamide / analogs & derivatives*,  chemistry,  pharmacology*
Propionibacterium acnes / immunology
Sebaceous Glands / drug effects,  metabolism
Zinc / pharmacology*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Drug Combinations; 0/nicomide; 7440-66-6/Zinc; 98-92-0/Niacinamide

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