Document Detail

A mechanism underlying mature-onset obesity: evidence from the hyperphagic phenotype of brain-derived neurotrophic factor mutants.
MedLine Citation:
PMID:  15142855     Owner:  NLM     Status:  MEDLINE    
Mice deficient in brain-derived neurotrophic factor (BDNF) develop mature-onset obesity, primarily due to overeating. To gain insight into the mechanism of this hyperphagia, we characterized food intake, body weight, meal pattern, and meal microstructure in young and mature mice fed balanced or high-fat diets. Hyperphagia and obesity occurred in mature but not young BDNF mutants fed a balanced diet. This hyperphagia was mediated by increased meal number, which was associated with normal meal size, meal duration, and satiety ratio. In contrast, the high-fat diet induced premature development of hyperphagia and obesity in young BDNF mutants and a similar magnitude hyperphagia in mature mutants. This hyperphagia was supported by increased meal size and was accompanied by a reduced satiety ratio. Thus the mechanism underlying hyperphagia was present before significant weight gain, but whether it occurred, and whether meal frequency or meal size was altered to support it, was modulated by a process associated with aging and by diet properties. Meal pattern changes associated with the balanced diet suggested meal initiation, and the oropharyngeal positive feedback that drives feeding, were enhanced and might have contributed to overeating in BDNF mutants, whereas negative feedback was normal. Consistent with this hypothesis, meal microstructure revealed that all hyperphagic mutant groups exhibited increased intake rates at meal onset. Therefore, the central nervous system targets of BDNF actions may include orosensory brain stem neurons that process and transmit positive feedback or forebrain neurons that modulate its strength.
Edward A Fox; Mardi S Byerly
Related Documents :
18753445 - Growth performance of broiler chickens fed diets containing shea nut (vitellaria parado...
9650015 - Comparison of three fatty meals in healthy normolipidaemic men: high post-prandial reti...
3568405 - The fat meal test of malabsorption: some further experience.
6940025 - Comparison of three methods to estimate steatorrhoea.
20695425 - Ewe's diet (pasture vs grain-based feed) affects volatile profile of cooked meat from l...
23031185 - Antioxidative activity and protective effect of probiotics against high-fat diet-induce...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  286     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-14     Completed Date:  2004-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R994-1004     Citation Subset:  IM    
Behavioral Neurogenetics Laboratory, Ingestive Behavior Research Center and Department of Psychological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age of Onset
Body Weight / physiology
Brain-Derived Neurotrophic Factor / genetics*
Eating / physiology
Hyperphagia / genetics*
Mice, Knockout
Mutation / genetics*
Obesity / genetics*,  pathology
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression.
Next Document:  Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in ...