Document Detail


The mechanism of synovial fluid retention in pressurized joint cavities.
MedLine Citation:
PMID:  16207630     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Hyaluronan (HA) in synovial fluid is vital to fluid retention in joint cavities. This study aims to evaluate a HA concentration polarization hypothesis and to examine, quantitatively, the agreement between theoretical predictions and experimental results. METHODS: A non-steady-state model was developed for HA ultrafiltration and concentration polarization on the synovial surface. The Kedem-Katchalsky equation was used to calculate the trans-synovial filtration rate Q as the HA concentration polarization layer built up. Model parameters were based on data from experiments. Effects of parameters on fluid filtration were investigated. RESULTS: The HA osmotic pressure at the synovial surface was found to approach the intra-articular pressure, P, during fluid infusion. The model simulated the experimentally observed decay in Q with the time at constant P, and predicted nonlinear P-Q relations in good agreement with experimental results over a range of bulk HA concentrations, from pathological (0.2 g L(- 1)) to physiological (4.0 g L(-1)). It gave quantitative insights into the development of the osmotic pressure and the significance of the HA reflection coefficient. CONCLUSIONS: The osmotic pressure of a HA concentration polarization layer on the synovial surface leads to outflow buffering. This provides the mechanism by which the vital lubricating synovial fluid is retained in a joint cavity under pressure.
Authors:
Y Lu; J R Levick; W Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  12     ISSN:  1073-9688     ISO Abbreviation:  Microcirculation     Publication Date:    2005 Oct-Nov
Date Detail:
Created Date:  2005-10-06     Completed Date:  2006-01-27     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  581-95     Citation Subset:  IM    
Affiliation:
Medical Engineering Division, Department of Engineering, Queen Mary, University of London, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Hyaluronic Acid / metabolism*
Joints / physiology*
Models, Psychological*
Pressure
Synovial Fluid / physiology*
Synovial Membrane / physiology*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
9004-61-9/Hyaluronic Acid
Comments/Corrections
Erratum In:
Microcirculation. 2006 Mar;13(2):173-4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Interleukin-1beta reduces transcellular monocyte diapedesis and compromises endothelial adherens jun...
Next Document:  Murine chemokine CXCL2/KC is a surrogate marker for angiogenic activity in the inflammatory granulat...