| On the mechanism of the probabilistic nature of ventricular defibrillation threshold. | |
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MedLine Citation:
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PMID: 12388279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The probabilistic nature of the ventricular defibrillation threshold (DFT) remains poorly understood. We hypothesized that shock outcome is a function of the amount of myocardium in its vulnerable period (VP). The endocardial surface of five isolated, perfused swine right ventricles was mapped with 477 bipolar electrodes during ventricular fibrillation (VF). Shock parameters and VF cycle length were not significantly different in the successful (S; n = 26) and failed (F; n = 26) trials. At the instant of the shock, the number of sites with 45- to 55-ms recovery was significantly smaller in the S trials than the F trials (P < 0.04). No significant difference in the number of sites with recovery intervals outside the 45- to 55-ms range was seen in S and F shocks. Endocardial action potential showed that a recovery time of 45-55 ms corresponded to the VP spanning -15 to -60 mV in 92% of the regenerative action potentials. We conclude that the probabilistic nature of the DFT is related to the amount of myocardium in its VP. |
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Authors:
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Masaaki Yashima; Young-Hoon Kim; Sean Armin; Tsu-Juey Wu; Yasushi Miyauchi; William J Mandel; Peng-Sheng Chen; Hrayr S Karagueuzian |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2002-09-26 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 284 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2002-12-17 Completed Date: 2003-01-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H249-55 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Cedars-Sinai Medical Center, Department of Medicine, School of Medicine, University of California, Los Angeles 90048, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Differential Threshold Electric Countershock* Electrophysiology Models, Statistical* Swine Treatment Failure Ventricular Fibrillation / physiopathology, therapy* |
| Grant Support | |
ID/Acronym/Agency:
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HL-52319/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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