| The mechanism of preventive effect of captopril on renal ischemia reperfusion injury is independent of ATP dependent potassium channels. | |
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MedLine Citation:
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PMID: 19079539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Renal ischemia reperfusion (IR) injury has been a major source of concern during the past decades and angiotensin converting enzyme (ACE) inhibitors have been successfully used to prevent this injury. There have been some controversial reports about the involvement of K(ATP) channels in the mechanism of action of ACE inhibitors. In this study, we examined the effect of K(ATP) channel blocker (Glibenclamide) on preventive effect of captopril on renal IR injury. METHODS: Male sprauge-dawley rats were pretreated with glibenclamide (1, 5 and 25 mg/kg) and/or captopril (5 mg/kg). They were anesthetized using ketamine (50 mg/kg) and xylazine (10 mg/kg). The left flank was incised and the left renal artery was clamped for 30 minutes. After that, the kidney was reperfused for 2 hours and then the animal was killed. The Right and left kidneys were removed and evaluated for microscopic damage. RESULTS: Captopril reduced renal IR injury while glibenclamide by itself caused no change. Glibenclamide did not change the preventive effect of captopril. CONCLUSION: It seems that the preventive effect of captopril is not directly mediated by K(ATP) channels and further attention should be paid to other receptor-mediated angiotensin II effects. |
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Authors:
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Rouhollah Habibey; Marjan Ajami; Ali Hesami; Hamidreza Pazoki-Toroudi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Iranian biomedical journal Volume: 12 ISSN: 1028-852X ISO Abbreviation: Iran. Biomed. J. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-05-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9814853 Medline TA: Iran Biomed J Country: Iran |
Other Details:
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Languages: eng Pagination: 241-5 Citation Subset: IM |
Affiliation:
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Dept. of Physiology, Iran University of Medical Sciences, Tehran, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Captopril / therapeutic use* Dose-Response Relationship, Drug Glyburide / therapeutic use KATP Channels / metabolism Kidney / injuries*, metabolism Male Rats Rats, Sprague-Dawley Reperfusion Injury / metabolism, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/KATP Channels; 10238-21-8/Glyburide; 62571-86-2/Captopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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