Document Detail

A mechanism of peripheral spread or localization of inflammatory reactions--role of the localized ground substance adaptive phenomenon.
MedLine Citation:
PMID:  2779476     Owner:  NLM     Status:  MEDLINE    
It is known that connective tissue-active peptides (CTAP) are released at sites of inflammation. Some of this material diffuses to immediately adjacent tissue and increases ground substance viscosity and fibroblast proliferation. This contributes to host protection against spread of infections and tumors. In a person with normal inflammatory reactivity, it should prevent spread of mediators and products of local inflammation. However, the host with an increased reactivity in sites of increased ground substance viscosity or who is highly reactive to dilution of tissue fluid would respond with more inflammation. A non-infectious, non-malignant process in a host with a highly reactive inflammatory or immune response could end up with peripheral spread. This could occur in any tissue but it occurs with great vigor in the skin. It could present as a peripheral extension of a local disease process, such as psoriasis, or the migration of cyclic lesions with clearing of the central area. There are over a dozen variants of peripherally spreading, ringed lesions described in the dermatologic literature. This includes erythema marginatum of rheumatic fever, erythema gyratum repens associated with cancer, and erythema annulare centrificum associated with allergic reactions to fungi. Many of the ringed dermatologic lesions have an immunologic component. They tend to be associated with inflammatory immune reactions at distant sites. Dermatologists have been gathering information on the ringed phenomenon at least since Hebra in 1854. The acute localized ground substance adaptive phenomenon is a broadly beneficial biologic response.(ABSTRACT TRUNCATED AT 250 WORDS)
O J Stone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  29     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-10-13     Completed Date:  1989-10-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  167-9     Citation Subset:  IM    
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MeSH Terms
Adaptation, Physiological
Connective Tissue / physiopathology
Inflammation / etiology*,  physiopathology
Models, Biological
Peptides / physiology
Reg. No./Substance:
0/Peptides; 69344-77-0/connective tissue-activating peptide

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