| On the mechanism of malonyl-CoA-independent fatty-acid synthesis. Characterization of the mitochondrial chain-elongating system of rat liver and pig-kidney cortex. | |
| | |
MedLine Citation:
|
PMID: 237759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. Chain elongation of fatty acids by extracts of mitochondrial acetone powders from rat liver and pig kidney cortex are similar in their properties. The specific activity of the kidney system is about 30% as compared to the liver system 2. Different incorporation rates [1-14-C] acetate into fatty acids in the presence of NADH as the sole hydrogen donor that were reported in literature can be explained by different extraction methods. 3. In liver the incorporation into the saturated fatty acid, elongated by one C-2 unit, amounts to only 19% with NADH and 60% with NADPH in comparison with the incorporation in presence of both nucleotides. 4. Kinetics of the chain-elongating process favour the enoyl-CoA reductase to be the rate limiting step. 5. Long-chain saturated and unsaturated fatty acyl-CoA derivatives are very poor primers of the chain elongation. 6. Possion and the enoyl-CoA reductase may be the transfer of hydrogen from NADPH to the respiratory chain, and the conservation of reducing equivalents (NADH and NADPH) or acetate units during cellular anoxia. |
| | |
Authors:
|
W Hinsch; W Seubert |
Related Documents
:
|
8897869 - 13c isotopomer model for estimation of anaplerotic substrate oxidation via acetyl-coa. 14707139 - An alternative pathway of oleate beta-oxidation in escherichia coli involving the hydro... 2222999 - The effect of methyl lidocaine on lysophospholipid metabolism in hamster heart. 1120139 - Fatty acid metabolism in the microsomal fraction of developing rabbit brain. 12796309 - Mfe1, a member of the peroxisomal hydroxyacyl coenzyme a dehydrogenase family, affects ... 16665049 - Activity of acyl carrier protein isoforms in reactions of plant fatty acid metabolism. 22121679 - Catalytic pyrolysis of oil fractions separated from food waste leachate over nanoporous... 10456099 - Training in the morris water maze occludes the synergism between acpd and arachidonic a... 21694669 - Synthetic dye - inorganic salt hybrid colorants for application in thermoplastics. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of biochemistry / FEBS Volume: 53 ISSN: 0014-2956 ISO Abbreviation: Eur. J. Biochem. Publication Date: 1975 May |
Date Detail:
|
Created Date: 1975-10-07 Completed Date: 1975-10-07 Revised Date: 2007-07-23 |
Medline Journal Info:
|
Nlm Unique ID: 0107600 Medline TA: Eur J Biochem Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 437-47 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetates
/
metabolism Acetyl Coenzyme A / metabolism Animals Chromatography, Gas Coenzyme A / pharmacology* Fatty Acids / biosynthesis* Kidney Cortex / metabolism* Kinetics Malonates / pharmacology* Mitochondria / metabolism* Mitochondria, Liver / metabolism* NAD NADP Organ Specificity Oxidation-Reduction Rats Species Specificity Swine Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Acetates; 0/Fatty Acids; 0/Malonates; 53-59-8/NADP; 53-84-9/NAD; 72-89-9/Acetyl Coenzyme A; 85-61-0/Coenzyme A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Proton-magnetic-resonance spectroscopic study of the histidine residues of bovine alpha-lactalbumin.
Next Document: The conformation of the RNA in cowpea chlorotic mottle virus: dye-binding studies.