Document Detail

On the mechanism of malonyl-CoA-independent fatty-acid synthesis. Characterization of the mitochondrial chain-elongating system of rat liver and pig-kidney cortex.
MedLine Citation:
PMID:  237759     Owner:  NLM     Status:  MEDLINE    
1. Chain elongation of fatty acids by extracts of mitochondrial acetone powders from rat liver and pig kidney cortex are similar in their properties. The specific activity of the kidney system is about 30% as compared to the liver system 2. Different incorporation rates [1-14-C] acetate into fatty acids in the presence of NADH as the sole hydrogen donor that were reported in literature can be explained by different extraction methods. 3. In liver the incorporation into the saturated fatty acid, elongated by one C-2 unit, amounts to only 19% with NADH and 60% with NADPH in comparison with the incorporation in presence of both nucleotides. 4. Kinetics of the chain-elongating process favour the enoyl-CoA reductase to be the rate limiting step. 5. Long-chain saturated and unsaturated fatty acyl-CoA derivatives are very poor primers of the chain elongation. 6. Possion and the enoyl-CoA reductase may be the transfer of hydrogen from NADPH to the respiratory chain, and the conservation of reducing equivalents (NADH and NADPH) or acetate units during cellular anoxia.
W Hinsch; W Seubert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of biochemistry / FEBS     Volume:  53     ISSN:  0014-2956     ISO Abbreviation:  Eur. J. Biochem.     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-10-07     Completed Date:  1975-10-07     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  0107600     Medline TA:  Eur J Biochem     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  437-47     Citation Subset:  IM    
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MeSH Terms
Acetates / metabolism
Acetyl Coenzyme A / metabolism
Chromatography, Gas
Coenzyme A / pharmacology*
Fatty Acids / biosynthesis*
Kidney Cortex / metabolism*
Malonates / pharmacology*
Mitochondria / metabolism*
Mitochondria, Liver / metabolism*
Organ Specificity
Species Specificity
Time Factors
Reg. No./Substance:
0/Acetates; 0/Fatty Acids; 0/Malonates; 53-59-8/NADP; 53-84-9/NAD; 72-89-9/Acetyl Coenzyme A; 85-61-0/Coenzyme A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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