Document Detail

The mechanism of the inactivation of human fibroblast interferon by mechanical stress.
MedLine Citation:
PMID:  894266     Owner:  NLM     Status:  MEDLINE    
Interferon derived from human fibroblasts is readily inactivated during agitation and filtration. This inactivation has been shown to be largely a product of mechanical stress, and has been studied in detail by subjecting interferon to controlled shear stress using a rotational viscometer. The possible mechanism of this phenomenon is discussed.
T Cartwright; O Senussi; M D Grady
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of general virology     Volume:  36     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-10-14     Completed Date:  1977-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  317-21     Citation Subset:  IM    
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MeSH Terms
Cell Line
Cytopathogenic Effect, Viral / drug effects
Drug Stability
Interferons / biosynthesis,  pharmacology*
Lung / embryology
Sindbis Virus / drug effects,  growth & development
Stress, Mechanical*
Reg. No./Substance:

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