| A mechanism of hypoxemia during hemodialysis. Consumption of CO2 in metabolism of acetate. | |
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MedLine Citation:
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PMID: 3933349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study is an investigation of the role of acetate metabolism in dialysis-induced hypoxemia and of the relative roles of acetate metabolism, bicarbonate loss, and CO2 gas (g) loss in causation of hypoxemia. The loss of CO2 (g) measured in 23 patients during acetate dialysis was found to be negligible (0.21 +/- 0.01 mmol/min). The HCO-3 loss was substantial (3.4 +/- 0.5 mmol/min), but its predicted effect on dialysis hypoxemia was modest. The infusion of acetate at 4 mmol/min into 6 normal volunteers decreased the respiratory exchange ratio (R) from 0.83 +/- 0.06 to 0.71 +/- 0.06 with constant O2 consumption (VO2) and reduced net CO2 production (VCO2). In another experiment, the infusion of sodium acetate into 9 normal volunteers resulted in a similar reduction in R (from 0.82 +/- 0.04 to 0.71 +/- 0.04) and arterial pO2 (from 92.3 +/- 1.1 to 78.3 +/- 1.7 mm Hg). The results indicate that acetate metabolism can lead to reduction in R and hypoxemia and suggest that the same mechanism is responsible for hypoxemia during hemodialysis using acetate dialysate. |
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Authors:
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M S Oh; J Uribarri; M L Del Monte; W F Heneghan; C S Kee; E A Friedman; H J Carroll |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of nephrology Volume: 5 ISSN: 0250-8095 ISO Abbreviation: Am. J. Nephrol. Publication Date: 1985 |
Date Detail:
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Created Date: 1985-12-09 Completed Date: 1985-12-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 366-71 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acid Acetic Acids / metabolism Anoxia / etiology*, metabolism Bicarbonates / metabolism Carbon Dioxide / metabolism Humans Oxygen / metabolism Pulmonary Gas Exchange Renal Dialysis / adverse effects*, methods |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 0/Bicarbonates; 124-38-9/Carbon Dioxide; 64-19-7/Acetic Acid; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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