Document Detail


The mechanism of hyperchemotaxis in Behçet's disease.
MedLine Citation:
PMID:  7218257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We previously reported that the chemotactic response of granulocytes from the patients with Behcet's disease is higher than normal neutrophils. In this study we examined the mechanism by which neutrophils from the patients with Behcet's disease were hyperchemotactic. Normal and patients' leukocytes were disrupted in hypertonic sucrose, sonicated and the supernate was examined. The extracts from the disrupted Behcet's neutrophils increased the normal granulocyte response to the chemotactic stimulus more strongly than extracts from normal cells. This active substance was localized mainly in the cytoplasmic fraction of leukocytes. The fact that Behcet's neutrophils have a higher concentration of the cytoplasmic activator might play an important role in the pathogenesis of hyperchemotaxis.
Authors:
A Takeuchi; K Kobayashi; M Mori; Y Mizushima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  8     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:    1981 Jan-Feb
Date Detail:
Created Date:  1981-06-25     Completed Date:  1981-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  40-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Behcet Syndrome / immunology*
Cell Fractionation
Chemotaxis, Leukocyte*
Glucuronidase / analysis
Granulocytes / enzymology
Humans
L-Lactate Dehydrogenase / analysis
Neutrophils / immunology
Chemical
Reg. No./Substance:
EC 1.1.1.27/L-Lactate Dehydrogenase; EC 3.2.1.31/Glucuronidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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