| The mechanism of hyperchemotaxis in Behçet's disease. | |
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MedLine Citation:
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PMID: 7218257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously reported that the chemotactic response of granulocytes from the patients with Behcet's disease is higher than normal neutrophils. In this study we examined the mechanism by which neutrophils from the patients with Behcet's disease were hyperchemotactic. Normal and patients' leukocytes were disrupted in hypertonic sucrose, sonicated and the supernate was examined. The extracts from the disrupted Behcet's neutrophils increased the normal granulocyte response to the chemotactic stimulus more strongly than extracts from normal cells. This active substance was localized mainly in the cytoplasmic fraction of leukocytes. The fact that Behcet's neutrophils have a higher concentration of the cytoplasmic activator might play an important role in the pathogenesis of hyperchemotaxis. |
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Authors:
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A Takeuchi; K Kobayashi; M Mori; Y Mizushima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of rheumatology Volume: 8 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1981 Jan-Feb |
Date Detail:
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Created Date: 1981-06-25 Completed Date: 1981-06-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
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Languages: eng Pagination: 40-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Behcet Syndrome / immunology* Cell Fractionation Chemotaxis, Leukocyte* Glucuronidase / analysis Granulocytes / enzymology Humans L-Lactate Dehydrogenase / analysis Neutrophils / immunology |
| Chemical | |
Reg. No./Substance:
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EC 1.1.1.27/L-Lactate Dehydrogenase; EC 3.2.1.31/Glucuronidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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