Document Detail


The mechanism of the formation and secretion of chylomicrons.
MedLine Citation:
PMID:  20493784     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The purpose of this review is to update the reader on our current understanding of the uptake and secretion of dietary lipid by the enterocyte to the periphery. This is a multi-stage process that first involves luminal digestion, followed by cellular uptake and processing, and subsequent extracellular transport of chylomicrons. We discuss the importance of acid and pancreatic lipase in lipid digestion. Micellar solubilization of fatty acids and 2-mono-acyl glycerol is critical to uptake by enhancing enterocyte exposure. There is controversy regarding the mechanism of fatty acid uptake by the enterocyte and whether this is mediated by a carrier-dependent process. The mechanism of fatty acid transport to the endoplasmic reticulum is discussed including the role of fatty acid binding proteins. Intracellularly, 2-monoacylglycerol and fatty acid are reconstituted to form triacylglycerol by the action of MGAT and DGAT. We focus on the mechanisms of intracellular chylomicron formation and secretion into lymph. Chylomicron and VLDL particles differ not only by an operational definition but likely represent two distinct pathways of intestinal lipoprotein formation. The physiologic role of apo B-48 in the intestine is presented as well as clinical disease of chylomicron metabolism, specifically abetalipoproteinemia and Anderson's disease.
Authors:
Tammy Kindel; Dana M Lee; Patrick Tso
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis. Supplements     Volume:  11     ISSN:  1878-5050     ISO Abbreviation:  Atheroscler Suppl     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100973461     Medline TA:  Atheroscler Suppl     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ireland Ltd.
Affiliation:
University of Cincinnati College of Medicine, United States.
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