Document Detail


The mechanism of cytolytic and cytostatic activity of benfluron.
MedLine Citation:
PMID:  3374709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Benfluron at concentrations of 0.26 and 0.52 mumol l-1 inhibited the formation of V79 colonies in a concentration-dependent way. Diminution of the size of colonies of the treated cells was accompanied by a decrease in protein content per cell. At the same time an increase in metabolic activity was observed. Benfluron blocked the V79 cells in S and G2 phases of the cell cycle and at higher concentrations induced cell lysis documented by alterations in cell membrane permeability and morphology. The in vitro membrane effect of benfluron involved a biphasic modulation of the cardiac sarcolemmal (Na+ + K+)-ATPase activity.
Authors:
K Horáková; D Lukácová; J Kozánková; A Dzurba; A Ziegelhöffer; S Jantová
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neoplasma     Volume:  35     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  1988  
Date Detail:
Created Date:  1988-06-27     Completed Date:  1988-06-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  177-84     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Biochemistry, Slovak Technical University, Bratislava, Czechoslovakia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / pharmacology*
Cell Cycle / drug effects*
Cell Line
Cell Survival / drug effects*
Fluorenes / pharmacology*
Kinetics
Microscopy, Electron, Scanning
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Fluorenes; 78250-23-4/VUFB 13468

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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