Document Detail


The mechanism of carvedilol in experimental viral myocarditis.
MedLine Citation:
PMID:  22443630     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carvedilol is a nonselective β-blocker with α1-adrenergic blocking and antioxidant properties. A number of preclinical experiments and clinical trials have demonstrated that carvedilol provides prominent benefit in heart failure. However, less research has been done in the area of animal models of viral myocarditis. This paper reviews the use of carvedilol in animal models of viral myocarditis. The experimental evidence strongly suggests that carvedilol, but not metoprolol (a selective β1-adrenergic blocking agent), protects against viral myocarditis and the superior cardioprotection effect of carvedilol to metoprolol may be due to its upregulating the production of antiinflammatory cytokines, downregulating the production of proinflammatory cytokines, antioxidative effects, the suppression of matrix metalloproteinases production, and positive hemodynamic effects.
Authors:
Li Yue-Chun; Ge Li-Sha; Guan Xue-Qiang; Lin Jia-Feng
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  18     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-26     Completed Date:  2012-10-17     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1620-4     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China. liyuechun1980@sina.com.cn
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacology,  therapeutic use
Animals
Carbazoles / pharmacology*,  therapeutic use
Disease Models, Animal*
Mice
Myocarditis / prevention & control*,  virology*
Propanolamines / pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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