| The mechanism of cartilage subdivision in the reorganization of the zebrafish pectoral fin endoskeleton. | |
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MedLine Citation:
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PMID: 21834126 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A cartilaginous pectoral fin endoskeleton in zebrafish (Danio rerio) develops early, after which the cartilage of the larval fin endoskeleton undergoes a complete transformation into the adult morphology. This transformation includes multiple subdivisions of a single cartilaginous disk. The type of cartilage subdivision is unique to teleost fish. In this study, we present the timing and the developmental features of these subdivisions and we discuss variation in this process, caused by differences in growth rate. We establish that the cartilage subdivisions are developmentally linked to the formation of lepidotrichia in the fin fold. At the cellular level, we show that neither apoptosis nor resorption by chondroclasts and/or macrophages contributes to the cartilage subdivision. Ultrastructural observations show dedifferentiation of chondrocytes in subdivision zones. Different from forelimb development in other vertebrates, dedifferentiation is an important mechanism in the development of the adult pectoral fin skeleton. We here provide further support for the idea that the phenotype of skeletal tissues is not terminal and that plasticity of differentiated connective tissues can play an important role in various developmental and homeostatic processes. J. Exp. Zool. (Mol. Dev. Evol.) 314B, 2011. © 2011 Wiley-Liss, Inc. |
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Authors:
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Jasper Dewit; P Eckhard Witten; Ann Huysseune |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-10 |
Journal Detail:
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Title: Journal of experimental zoology. Part B, Molecular and developmental evolution Volume: - ISSN: 1552-5015 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168228 Medline TA: J Exp Zool B Mol Dev Evol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc., A Wiley Company. |
Affiliation:
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Research Group Evolutionary Developmental Biology, Biology Department, Ghent University, Ghent, Belgium. jasper.dewit@ugent.be. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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