Document Detail

A mechanism of carbamazepine-analgesia as shown by bradykinin-induced trigeminal pain.
MedLine Citation:
PMID:  6850364     Owner:  NLM     Status:  MEDLINE    
Single neuronal responses induced by micro-application of bradykinin solution to the tooth pulp of the rabbit were recorded in the subnucleus reticularis dorsalis and trigeminal subnucleus caudalis and characterized by intermittent episodes of paroxysmal activities. Carbamazepine, the primary agent for trigeminal neuralgia, suppressed such a paroxysmal response, suggesting that an analgesic action of the drug results from the suppression of synaptic transmission at the subnucleus reticularis dorsalis and trigeminal subnucleus caudalis.
M Satoh; F W Foong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research bulletin     Volume:  10     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-07-15     Completed Date:  1983-07-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  407-9     Citation Subset:  IM    
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MeSH Terms
Bradykinin / pharmacology*
Carbamazepine / therapeutic use*
Dental Pulp / drug effects,  innervation
Neurons / drug effects,  physiology
Pain / physiopathology*
Trigeminal Nuclei / drug effects,  physiopathology*
Reg. No./Substance:
298-46-4/Carbamazepine; 58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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