| A mechanism of cadmium poisoning: the cross effect of calcium and cadmium in the calmodulin-dependent system. | |
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MedLine Citation:
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PMID: 2350237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of the intraventricular (IVT) administration of cadmium on the amount of dopamine (DA) in various regions of the mice brain were analyzed immunohistochemically using a microphotometry system. DA levels in the neostriatum and nucleus accumbens were increased by approximately 30% (p less than 0.01) by the IVT administration of CdCl2 (1 mumol/kg). This effect was abolished by the calmodulin antagonist, W-7 (4.2 micrograms/mouse, IVT). The effects of cadmium on DA levels in the brain were very similar to those seen with calcium. Combining these results with our previous finding that calmodulin does not have the ability to distinguish between calcium and cadmium, a mechanism of cadmium poisoning is suggested in which cadmium activates catecholamine synthesizing enzyme and numerous other enzymes through calmodulin-dependent systems, thereby disturbing many functions in the organism. |
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Authors:
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D Sutoo; K Akiyama; S Imamiya |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of toxicology Volume: 64 ISSN: 0340-5761 ISO Abbreviation: Arch. Toxicol. Publication Date: 1990 |
Date Detail:
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Created Date: 1990-07-09 Completed Date: 1990-07-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0417615 Medline TA: Arch Toxicol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 161-4 Citation Subset: IM |
Affiliation:
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Institute of Medical Science, University of Tsukuba, Ibaraki, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects Cadmium Poisoning / metabolism* Calcium / physiology* Calmodulin / antagonists & inhibitors, physiology* Dopamine / metabolism Immunohistochemistry Injections, Intraventricular Male Mice Mice, Inbred Strains Sulfonamides / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Calmodulin; 0/Sulfonamides; 65595-90-6/W 7; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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