Document Detail

The mechanism of action of the hypocholesterolemic drug p-(1-adamantyloxy)-aniline.
MedLine Citation:
PMID:  7259818     Owner:  NLM     Status:  MEDLINE    
The effect of p-(1-adamantyloxy)-aniline (AOA) on the biliary secretion of cholesterol, bile salts, and phospholipids was studied in hypercholesterolemic rats. A second study was conducted using hypercholesterolemic rats with 14C-labeled cholesterol pools for the purpose of determining the effects of AOA on cholesterol metabolism. Treatment with AOA (100 mg/kg, orally) daily for 1 week resulted in the increased secretion of biliary cholesterol, but did not affect the secretion of bile salts or phospholipids. This treatment also resulted in an increase in the fecal excretion of 14C-labeled neutral and acidic sterols, and in reductions of both the total radioactivity in the liver and liver cholesterol. The data presented support the conclusion that the hypocholesterolemic action of AOA is due to the increased secretion of cholesterol into the bile and to the increased fecal excretion of cholesterol and bile salts.
B D Rush; M J Ruwart; C E Day
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  39     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1981 Jun 
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  345-51     Citation Subset:  IM    
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MeSH Terms
Adamantane / analogs & derivatives*,  pharmacology
Aniline Compounds / pharmacology*
Anticholesteremic Agents / pharmacology*
Bile / metabolism
Cholesterol / metabolism
Feces / analysis
Lipid Metabolism
Liver / metabolism
Reg. No./Substance:
0/4-(1-adamantyloxy)aniline; 0/Aniline Compounds; 0/Anticholesteremic Agents; 281-23-2/Adamantane; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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