| The mechanism of action of angiostatin: can you teach an old dog new tricks? | |
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MedLine Citation:
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PMID: 11916069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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What is angiostatin? In 1994, Folkman and colleagues published a landmark paper describing anti-tumor effects in mice with a purified fragment of plasminogen they named angiostatin (1). Although many papers have been published describing activities of cryptic polypeptides derived from plasminogen fragments, this was the first report which associated plasminogen kringles 1-4 as a suppressor of metastasis development. This review will describe what is known about the mechanism of action of angiostatin from the current literature. |
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Authors:
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Tammy L Moser; M Sharon Stack; Miriam L Wahl; Salvatore V Pizzo |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 87 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-27 Completed Date: 2003-08-25 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: Germany |
Other Details:
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Languages: eng Pagination: 394-401 Citation Subset: IM |
Affiliation:
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Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA. tammy.havener@duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiogenesis Inhibitors
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chemistry,
pharmacology Angiostatins Animals Antineoplastic Agents / chemistry, pharmacology Binding Sites Humans Mitochondrial Proton-Translocating ATPases / antagonists & inhibitors Peptide Fragments / chemistry, pharmacology, physiology* Plasminogen / chemistry, pharmacology, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/Antineoplastic Agents; 0/Peptide Fragments; 86090-08-6/Angiostatins; 9001-91-6/Plasminogen; EC 3.6.3.-/Mitochondrial Proton-Translocating ATPases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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