Document Detail


The mechanics of notochord elongation, straightening and stiffening in the embryo of Xenopus laevis.
MedLine Citation:
PMID:  2081454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have examined the biomechanical development of the notochord of Xenopus early tail-bud embryos by: (1) quantifying morphological and mechanical changes in the embryo during stages 20-28, and (2) conducting manipulative experiments to elucidate mechanical roles of various components of the notochord. The notochord, which is composed of a stack of flat cells surrounded by a connective tissue sheath, elongates dramatically and begins straightening between stages 21 and 25. At this time the fiber density in the notochord sheath goes up, the osmotic activity of the notochord cells increases, vacuoles within these cells swell, the internal pressure of the notochord increases 2- to 3-fold, and the flexural stiffness of the notochord rises by an order of magnitude. We suggest that the tendency of the notochord cells to osmotically swell is resisted by the sheath, thereby permitting the internal pressure to rise. This pressure increase results in the greater stiffness that permits the notochord to elongate and straighten without being buckled by the surrounding tissues.
Authors:
D S Adams; R Keller; M A Koehl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  110     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-05-03     Completed Date:  1991-05-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  115-30     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of California, Berkeley 94720.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Microscopy, Electron, Scanning
Notochord / physiology*,  ultrastructure
Osmosis
Xenopus laevis / embryology*
Grant Support
ID/Acronym/Agency:
HD18979/HD/NICHD NIH HHS; HD25594/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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